Assay of urinary protein carbonyl content can predict the steroid dependence and resistance in children with idiopathic nephrotic syndrome
المؤلفون المشاركون
Gopal, Niranjan
Koner, Bidhan Chandra
Bhattacharjee, Atanu
Bhat, Vishnu
Murugaiyan, Sathish Babu
Muddegowda, Prakash H.
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 28، العدد 2 (30 إبريل/نيسان 2017)، ص ص. 268-272، 5ص.
الناشر
تاريخ النشر
2017-04-30
دولة النشر
السعودية
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Nephrotic syndrome in pediatric age is mostly idiopathic.
Idiopathic nephrotic syndrome (INS) by default is treated with steroids from the very beginning.
Some do not respond to steroids and are grouped later as either steroid-resistant (SR) or steroid-dependent (SD) cases.
The protein selectivity index often fails to predict the SR and SD cases.
The SD and SR cases of INS exhibit higher degrees of oxidative stress compared to steroid responders.
Proteins get carbonylated when they are exposed to free radicals.
The significance of excretion of these carbonylated proteins in urine is yet to be studied in detail.
In this study, 70 cases of INS were enrolled, and urinary protein carbonyl content (UPCC) was estimated by Levine’s method before starting the steroid therapy.
All the cases were followed up and, based on the response to steroid therapy, were grouped as Group A (n = 47).
Steroid sensitive and Group B (n = 23), SD + SR cases.
UPCC was significantly higher in Group B compared to Group A.
Receiver–operating curve showed at a cutoff limit of 5.10 nmoles/mg of protein, UPCC can predict SD or SR cases with 83.3% sensitivity and 85.2% specificity and area under the curve of 0.833, P <0.05.
UPCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gopal, Niranjan& Koner, Bidhan Chandra& Bhattacharjee, Atanu& Bhat, Vishnu& Murugaiyan, Sathish Babu& Muddegowda, Prakash H.. 2017. Assay of urinary protein carbonyl content can predict the steroid dependence and resistance in children with idiopathic nephrotic syndrome. Saudi Journal of Kidney Diseases and Transplantation،Vol. 28, no. 2, pp.268-272.
https://search.emarefa.net/detail/BIM-761838
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gopal, Niranjan…[et al.]. Assay of urinary protein carbonyl content can predict the steroid dependence and resistance in children with idiopathic nephrotic syndrome. Saudi Journal of Kidney Diseases and Transplantation Vol. 28, no. 2 (Mar. / Apr. 2017), pp.268-272.
https://search.emarefa.net/detail/BIM-761838
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gopal, Niranjan& Koner, Bidhan Chandra& Bhattacharjee, Atanu& Bhat, Vishnu& Murugaiyan, Sathish Babu& Muddegowda, Prakash H.. Assay of urinary protein carbonyl content can predict the steroid dependence and resistance in children with idiopathic nephrotic syndrome. Saudi Journal of Kidney Diseases and Transplantation. 2017. Vol. 28, no. 2, pp.268-272.
https://search.emarefa.net/detail/BIM-761838
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 271-272
رقم السجل
BIM-761838
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر