Association between angiotensin-converting enzyme insertion deletion gene polymorphism and end-stage renal disease in lebanese patients with diabetic nephropathy

المؤلفون المشاركون

Fawwaz, Sarah
Balba, Mahmud
Borjac, Jamilah
Fakhuri, Raja
Fakhuri, Hana

المصدر

Saudi Journal of Kidney Diseases and Transplantation

العدد

المجلد 28، العدد 2 (30 إبريل/نيسان 2017)، ص ص. 325-329، 5ص.

الناشر

المركز السعودي لزراعة الأعضاء

تاريخ النشر

2017-04-30

دولة النشر

السعودية

عدد الصفحات

5

التخصصات الرئيسية

الطب البشري

الموضوعات

الملخص EN

Diabetic nephropathy (DN) is one of the leading causes of end-stage renal disease (ESRD).

The development and progression of nephropathy is strongly determined by genetic factors, and few genes have been shown to contribute to DN.

An insertion/deletion (I/D) polymorphism of the gene encoding angiotensin-converting enzyme (ACE) was reported as a candidate gene predisposing to DN and ESRD.

Accordingly, we investigated the frequency of ACE I/D polymorphism in 50 patients with DN, of whom 33 had ESRD and compared them with 64 patients with type 2 diabetes mellitus (T2DM) but with normal renal function.

Polymerase chain reaction amplification, using specific primers, was performed to genotype ACE I/D.

Chi-square test was used to assess the differences between the groups.

The frequencies of the ACE genotypes were as follows: 48% D/D, 40% I/D, and 12% I/I in patients with DN in contrast to 32.8% D/D, 45.3% I/D, and 21.9% I/I in T2DM.

The distribution of the D/D, D/I, and I/I genotypes did not significantly differ between T2DM and DN.

However, having the D allele carried a risk for the development of DN [odds ratio (OD), 1.71, P = 0.054].

On the other hand, the distribution of the D/D, D/I, and I/I genotypes was significantly different between T2DM and ESRD patients, χ2 = 7.23, P = 0.027.

This was reflected by the D allele which carried a risk for the development of ESRD (OR, 2.51, P = 0.0057).

These findings suggest that the D allele may be considered as a risk factor for both the development of DN and the progression of DN to ESRD in Lebanese population with T2DM.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Fawwaz, Sarah& Balba, Mahmud& Fakhuri, Hana& Borjac, Jamilah& Fakhuri, Raja. 2017. Association between angiotensin-converting enzyme insertion deletion gene polymorphism and end-stage renal disease in lebanese patients with diabetic nephropathy. Saudi Journal of Kidney Diseases and Transplantation،Vol. 28, no. 2, pp.325-329.
https://search.emarefa.net/detail/BIM-761853

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Fawwaz, Sarah…[et al.]. Association between angiotensin-converting enzyme insertion deletion gene polymorphism and end-stage renal disease in lebanese patients with diabetic nephropathy. Saudi Journal of Kidney Diseases and Transplantation Vol. 28, no. 2 (Mar. / Apr. 2017), pp.325-329.
https://search.emarefa.net/detail/BIM-761853

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Fawwaz, Sarah& Balba, Mahmud& Fakhuri, Hana& Borjac, Jamilah& Fakhuri, Raja. Association between angiotensin-converting enzyme insertion deletion gene polymorphism and end-stage renal disease in lebanese patients with diabetic nephropathy. Saudi Journal of Kidney Diseases and Transplantation. 2017. Vol. 28, no. 2, pp.325-329.
https://search.emarefa.net/detail/BIM-761853

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 328-329

رقم السجل

BIM-761853