![](/images/graphics-bg.png)
Effect of bosentan and losartan on oxidative stress and cortisol level in endothelin-1 and angiotensin II treated rats
المؤلفون المشاركون
Hamad, Sarkawt Hamad Amin
Mahmud, Almas M. R.
Mawlud, Ismail Mustafa
المصدر
ZANCO Journal of Pure and Applied Sciences
العدد
المجلد 28، العدد 4 (31 أغسطس/آب 2016)، ص ص. 7-14، 8ص.
الناشر
جامعة صلاح الدين قسم النشر العلمي
تاريخ النشر
2016-08-31
دولة النشر
العراق
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The exact mechanism by which Endothelin-1 (ET-1), Angiotensin II (Ang II), and their antagonists act in physiology are controversial subjects among researchers, therefore the present work aimed to investigate the effects of bosentan and losartan on oxidative stress and serum cortisol level in rats.
This study includes two experiments.
The first one included four groups: The first group treated with saline, the second group treated with ET-1 , the third group treated with Bosentan + ET-1, and the fourth group treated with Losartan + ET-1.
The second experiment also included four groups: The first group treated with saline, the second group treated with Ang II , the third group treated with Losartan + Ang II, and the fourth group treated with Bosentan + Ang II.
The results demonstrate that, bolus infusion of losartan significantly decreased serum cortisol level versus ET-1.
Bosentan significantly decreased cortisol level compared with Ang II infusion.
Neither losartan nor Ang II changed serum cortisol significantly versus Ang II and saline groups.
Furthermore, bosentan caused rising in malondialdehyde (MDA) concentration compared to ET-1 infusion, but losartan slightly decreased it.
MDA in Ang II infusion dramatically became high in comparison with saline infusion, and both losartan.
Serum glucose concentration clearly rose in losartan infusion, while bosentan did affect it significantly.
Serum chloride in both bosentan and losartan significantly increased compared to ET-1.
Both ET-1 and Ang II infusions for one hour led to increasing Mg++ concentration versus saline infusion.
In conclusion, both ET-1 and Ang II antagonists reduced cortisol level , but they did not change lipid peroxidation marker as elevated by Ang II infusion.
Interestingly, ET-1 and Ang II markedly could increase serum Mg++ levels, but their antagonists did not return it to the normal levels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mahmud, Almas M. R.& Mawlud, Ismail Mustafa& Hamad, Sarkawt Hamad Amin. 2016. Effect of bosentan and losartan on oxidative stress and cortisol level in endothelin-1 and angiotensin II treated rats. ZANCO Journal of Pure and Applied Sciences،Vol. 28, no. 4, pp.7-14.
https://search.emarefa.net/detail/BIM-762105
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mahmud, Almas M. R.…[et al.]. Effect of bosentan and losartan on oxidative stress and cortisol level in endothelin-1 and angiotensin II treated rats. ZANCO Journal of Pure and Applied Sciences Vol. 28, no. 4 (2016), pp.7-14.
https://search.emarefa.net/detail/BIM-762105
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mahmud, Almas M. R.& Mawlud, Ismail Mustafa& Hamad, Sarkawt Hamad Amin. Effect of bosentan and losartan on oxidative stress and cortisol level in endothelin-1 and angiotensin II treated rats. ZANCO Journal of Pure and Applied Sciences. 2016. Vol. 28, no. 4, pp.7-14.
https://search.emarefa.net/detail/BIM-762105
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 12-14
رقم السجل
BIM-762105
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)