Utility of myelin basic protein as an early prognostic biomarker in multiple sclerosis
المؤلفون المشاركون
Pouragahi, Sami
NusayrI-Asl, Marjan
Banki, Abd al-Ali
Zamanzadeh, Zahrah
Ataei, Mitra
Sanati, Muhammad Husayn
Sadiqi, Mahdi
Sahraian, Muhammad Ali
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 19، العدد 3 (31 مارس/آذار 2017)، ص ص. 1-10، 10ص.
الناشر
تاريخ النشر
2017-03-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Myelin basic protein (MBP), a crucial neuro-autoantigen involved in the maintenance of the myelin sheath, is one of the biomarkers of therapeutic response in multiple sclerosis (MS).
Objectives : The study examines prognostic biomarker and molecular mimicry hypothesis MS etiology by MBP.
Methods : This study is convergence of three arms including in silico and in vitro (bioinformatics) with the in vivo (experimental).
A novel methodology combining molecular techniques was used toconfirmthe antigenic properties of MBPand study its efficiency in increasing the susceptibility to MS.
One hundred eighty MS patients and healthy subjects were recruited for the study from Jan 2013 to Feb 2016 in Iran.
Age and sex-matched healthy volunteers and patients were analyzed using various quantitative and qualitative molecular laboratory techniques.
Peripheral blood mononuclear cells (PBMCs) and plasma was used for the retrieval of MBP and IgG assay, respectively.
Results : The optimum concentration of the MBP epitope for the immune system to react and facilitate prognostication was found to be 50 and 150 _g/mL in MS patients and healthy individuals, respectively (P < 0.0001****).
Combined results from ELISA and realtime PCR showed that the total IgG and the ratio of gene expression for candidate human MBP epitope was higher in MS patients in all the three groups compared to that in healthy controls P < 0.0001****).
Conclusions : Molecular assays in the early stages of the disease could help in elucidating the effectiveness of theMBPas a prognostic factor in MS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pouragahi, Sami& NusayrI-Asl, Marjan& Sahraian, Muhammad Ali& Sadiqi, Mahdi& Banki, Abd al-Ali& Sanati, Muhammad Husayn…[et al.]. 2017. Utility of myelin basic protein as an early prognostic biomarker in multiple sclerosis. Iranian Red Crescent Medical Journal،Vol. 19, no. 3, pp.1-10.
https://search.emarefa.net/detail/BIM-766615
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sanati, Muhammad Husayn…[et al.]. Utility of myelin basic protein as an early prognostic biomarker in multiple sclerosis. Iranian Red Crescent Medical Journal Vol. 19, no. 3 (Mar. 2017), pp.1-10.
https://search.emarefa.net/detail/BIM-766615
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pouragahi, Sami& NusayrI-Asl, Marjan& Sahraian, Muhammad Ali& Sadiqi, Mahdi& Banki, Abd al-Ali& Sanati, Muhammad Husayn…[et al.]. Utility of myelin basic protein as an early prognostic biomarker in multiple sclerosis. Iranian Red Crescent Medical Journal. 2017. Vol. 19, no. 3, pp.1-10.
https://search.emarefa.net/detail/BIM-766615
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 9-10
رقم السجل
BIM-766615
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر