![](/images/graphics-bg.png)
Association of perilipin and insulin receptor substrate-1 genes polymorphism with lipid profiles, central obesity, and type 2 diabetes in a sample of an Iranian population
المؤلفون المشاركون
Saravani, Ramin
Nurzihi, Nafisah
Galavi, Hamid Rida
Ranjbar, Nisrin
Sargazi, Marzieh Lutfian
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 19، العدد 6 (30 يونيو/حزيران 2017)، ص ص. 1-9، 9ص.
الناشر
تاريخ النشر
2017-06-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Since insulin receptor substrate-1 (IRS-1) is the main substrate of the insulin receptor tyrosine kinase and has been detected to activate phosphatidylinositol (PI) 3-kinase and promote GLUT4 translocation, the IRS-1 gene is a possible candidate for development of type2 diabetes, insulin resistance, and obesity.
Preilipin (PLIN) coats intracellular lipid droplets and modulates adipocyte lipolysis.
Objectives : in this study, we investigated whether insulin receptor substrate-1 (IRS-1) and Perilipin (PLIN) genes polymorphism were associated with Type 2 diabetes (T2D), obesity, and lipid profiles in a sample of the Iranian population (Southeast of Iran).
Methods: In this randomized case-control study (Feb, 2016 to Sep, 2016), we genotyped 200 patients with T2D and the same number (200) of controls by using the combined nested-polymerase chain reaction (PCR) as well as the amplification refractory mutation system (ARMS)-PCR for IRS-1 variant and Tetra-ARMS-PCR for PLIN variant in southeast Iran (Zahedan).
Results : the polymorphism of 4578621 in the PLIN gene was associated with T2D.
GG genotype and G allele at rs4578621of PLIN gene were significantly higher in patients than in controls (for the G allele: OR = 2.31, 95%CI = 1.55 - 3.46, P < 0.0001; for the GG genotype : or = OR = 2.67, 95%CI = 1.71-4.19, P<0.0001).
Furthermore, women with fast blood glucose (FBG) < 110 mg/dL are in protection of diabetes (P < 0.001, OR = 0.561 (0.430 - 0.733), for women, (P = 0.002, OR = 0.481 95%CI: 0.305 - 0.756), for FBG, (P = 0.002, OR = 0.591, 95%CI = 0.422 - 0.829), for triglyceride (TG) < 130 mg/dL, and (P = 0.001, OR.
= 0.563, 95%CI = 0.407 - 0.780) for TG ≥ 130.
On the other hand, the polymorphism of 2943641 in IRS-1 gene was not associated with T2D (P = 0.08).
However, the frequencies of the risk A allele at rs29436411of IRS-1 was significantly higher in patients than in controls (G allele: OR = 0.55, 95% CI = 0.36 - 0.848, P = 0.0086).
Also detected, BMI ≥ 25 is a risk factor for diabetes in rs29436411of IRS-1 gene (P = 0.024, OR = 1.604 95%CI = 1.063 - 2.420).
Conclusions: The rs2943641 polymorphism of the IRS-1 gene is a major genetic determinant of obesity but not Type 2 diabetes and lipid profiles.
The rs4578621 polymorphism of the PLIN gene related with T2D and TG but not obesity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Saravani, Ramin& Nurzihi, Nafisah& Galavi, Hamid Rida& Ranjbar, Nisrin& Sargazi, Marzieh Lutfian. 2017. Association of perilipin and insulin receptor substrate-1 genes polymorphism with lipid profiles, central obesity, and type 2 diabetes in a sample of an Iranian population. Iranian Red Crescent Medical Journal،Vol. 19, no. 6, pp.1-9.
https://search.emarefa.net/detail/BIM-767668
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Saravani, Ramin…[et al.]. Association of perilipin and insulin receptor substrate-1 genes polymorphism with lipid profiles, central obesity, and type 2 diabetes in a sample of an Iranian population. Iranian Red Crescent Medical Journal Vol. 19, no. 6 (Jun. 2017), pp.1-9.
https://search.emarefa.net/detail/BIM-767668
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Saravani, Ramin& Nurzihi, Nafisah& Galavi, Hamid Rida& Ranjbar, Nisrin& Sargazi, Marzieh Lutfian. Association of perilipin and insulin receptor substrate-1 genes polymorphism with lipid profiles, central obesity, and type 2 diabetes in a sample of an Iranian population. Iranian Red Crescent Medical Journal. 2017. Vol. 19, no. 6, pp.1-9.
https://search.emarefa.net/detail/BIM-767668
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 7-9
رقم السجل
BIM-767668
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)