Variation in immunohistochemical expression of neuropilin1 among oral, laryngeal and skin SCC
المؤلفون المشاركون
Younis, Wasan H.
Abid, Khalid Jabbar
المصدر
Journal of Baghdad College of Dentistry
العدد
المجلد 29، العدد 1 (31 مارس/آذار 2017)، ص ص. 63-69، 7ص.
الناشر
تاريخ النشر
2017-03-31
دولة النشر
العراق
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : neuropilin 1(nrp1) is considered a novel non-tyrosine kinase co- receptor for the vascular endothelial growth factors (VEGF).
First discovered on migrating neurons.
NRP1is suggested to be up-regulated in cells of different types of cancer and implicated with advanced disease.
The aim of this study was to investigate the variation in expression of NRP1 in oral, laryngeal and skin squamous cell carcinoma.
Materials and methods : tissue sections from 120 formalin fixed- paraffin embedded blocks histopathologically diagnosed as oral, laryngeal and skin SCC (40 blocks for each),immunohistohemically stained in immunoperoxidase method with monoclonal antibodies to NRP1, the localization of expression was examined and the resulting scores were analyzed according to age, sex, and histopathological grades.
Results : the immunohistochemical analysis revealed that the NRP1 expression in oral, laryngeal and skin squamous cell carcinoma was (87.5%), (92.2%) and (82.5%) respectively, with no significant variation in expression among them(P=0.44), but, NRP1 up-regulation in all the three types correlated positively with degree of differentiation (P=0.009), (P=0.002) and (P=0.007) respectively.
Conclusion : angiogenesis play an important and similar role in carcinogenesis of oral, laryngeal and skin squamous cell carcinoma, and NRP1 is significantly associated with degree of differentiation in the three types of carcinomaso it can be act as a prognostic marker.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abid, Khalid Jabbar& Younis, Wasan H.. 2017. Variation in immunohistochemical expression of neuropilin1 among oral, laryngeal and skin SCC. Journal of Baghdad College of Dentistry،Vol. 29, no. 1, pp.63-69.
https://search.emarefa.net/detail/BIM-769978
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abid, Khalid Jabbar& Younis, Wasan H.. Variation in immunohistochemical expression of neuropilin1 among oral, laryngeal and skin SCC. Journal of Baghdad College of Dentistry Vol. 29, no. 1 (Mar. 2017), pp.63-69.
https://search.emarefa.net/detail/BIM-769978
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abid, Khalid Jabbar& Younis, Wasan H.. Variation in immunohistochemical expression of neuropilin1 among oral, laryngeal and skin SCC. Journal of Baghdad College of Dentistry. 2017. Vol. 29, no. 1, pp.63-69.
https://search.emarefa.net/detail/BIM-769978
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 68-69
رقم السجل
BIM-769978
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر