Early detective biomarkers versus mriin assessment of hepatic focal lesions and early diagnosis of hepatocellular carcinoma in cirrhotic patients
العناوين الأخرى
دور الدلالات المعملية مقارنة بأشعة الرنين المغناطيسي في تقييم الإصابة البؤرية و التشخيص المبكر لسرطان الكبد في مرضى تليف الكبد
المؤلفون المشاركون
Abd al-Rahman, Muhammad Zakariyya
Muhammad, Hanan Sharaf al-Din
Hasan, Muhammad Husam al-Din
Abd al-Aziz, Wail Abd al-Jawad
Nijm, Dalya Ahmad Abd al-Fattah
al-Qadi, Rim Mustafa Muhammad Ali
Mahmud, Amal Abd al-Aziz
Radwan, Mustafa Izz al-Din Muhammad
Sulayman, Muna Muhammad
المصدر
العدد
المجلد 39، العدد 1 (31 يناير/كانون الثاني 2015)، ص ص. 29-46، 18ص.
الناشر
تاريخ النشر
2015-01-31
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Cirrhosis is ihe conséquence of a chronic diffuse parenchymal injury to ihe liver which cames cellidar necrosis and an inflammalory response.
The cirrhotic liver is therefore hy définition composed of a multUude of nodules.
MRI of the liver is an important lool for détection and characterization of focal liver lésions and for the évaluation of diffuse liver disease.
The use of epigenetic biomurkers is a noninvasive approach for early détection of hepatocellular carcinoma (HCC) in high-risk patients.
Patients and methods: Thirty cirrhotic patients with hepatic focal lésions out of 250 patients subjected to the following investigations: HCV anti-bodies, HBs antigen , Alfa fetoprotein (AFP).
Methylated gene pl5 and Adenomatous polyposis coli gene (APC) in sérum by Polymerase chain reaction (PCR), Liver biopsy, Abdominal Ultrasound, Doppler US and MRI diffusion abdomen.
Results: iVlRI is the best imaging modality in détection and characterization of hepatic focai lésions and early diagnosis of HCC, methylated genepl5 is more sensitive and specific than MRI in deleclion of HCC.
An insignificant relationship was observed between âge and methylated gene pl5 and APC gene (p=0.765), (p=0.305) respectively.
Furthur more an insignificant relationship was fmnd belween gender and methylated gene pl5 and APC gene (p^O.593), (p=0.617) respectively.
An insignificant relationship was also observed between residence and methylated gene pl5 and APC gene (p=0.862), (p=0.745) respectively.
On the other hand a significant relationship was observed between methylated gene pl5 and HCV positive patients (p=0.004) as well as between methylated gene pi5 and AFP (p=0.003).
An insignificant relationship observed between APC gene and HCV positive patients (p=0.098) and AFP (p=0.236).
Also an insignificant relationship between methylated gene pl5, APC gene and MRI in diagnosis of HCC (p=^0.091), (p=0.429j respectively.
Conclusion: Methylated genes are more sensitive than MRI in détection of HCC.
Methylated gene pl5 and APC gene have insignificant relationship to âge, sex and residency.
Methylated gene pI5 has significant relationship to HCV positive patients and AFP.
Insignificant relationship between methylated gene pI5, APC gene and MRI in diagnosis of HCC.
Key words : Liver cirrhosis, MRI, HCC, Methylated gene pI5, APC gene.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hasan, Muhammad Husam al-Din& Sulayman, Muna Muhammad& Radwan, Mustafa Izz al-Din Muhammad& Abd al-Rahman, Muhammad Zakariyya& Muhammad, Hanan Sharaf al-Din& Abd al-Aziz, Wail Abd al-Jawad…[et al.]. 2015. Early detective biomarkers versus mriin assessment of hepatic focal lesions and early diagnosis of hepatocellular carcinoma in cirrhotic patients. Assiut Medical Journal،Vol. 39, no. 1, pp.29-46.
https://search.emarefa.net/detail/BIM-774242
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hasan, Muhammad Husam al-Din…[et al.]. Early detective biomarkers versus mriin assessment of hepatic focal lesions and early diagnosis of hepatocellular carcinoma in cirrhotic patients. Assiut Medical Journal Vol. 39, no. 1 (Jan. 2015), pp.29-46.
https://search.emarefa.net/detail/BIM-774242
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hasan, Muhammad Husam al-Din& Sulayman, Muna Muhammad& Radwan, Mustafa Izz al-Din Muhammad& Abd al-Rahman, Muhammad Zakariyya& Muhammad, Hanan Sharaf al-Din& Abd al-Aziz, Wail Abd al-Jawad…[et al.]. Early detective biomarkers versus mriin assessment of hepatic focal lesions and early diagnosis of hepatocellular carcinoma in cirrhotic patients. Assiut Medical Journal. 2015. Vol. 39, no. 1, pp.29-46.
https://search.emarefa.net/detail/BIM-774242
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 42-45
رقم السجل
BIM-774242
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر