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Effects of Canarium odontophyllum leaves on plasma glucose and T lymphocyte population in streptozotocin-induced diabetic rats
المؤلفون المشاركون
Basri, Dayang Fredalina
Saari, Shafikha Mohd
Budin, Siti Balkis
Warif, Nur Malia Abd
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 24، العدد 2 (28 فبراير/شباط 2017)، ص ص. 320-323، 4ص.
الناشر
تاريخ النشر
2017-02-28
دولة النشر
السعودية
عدد الصفحات
4
التخصصات الرئيسية
الموضوعات
الملخص EN
Type 1 diabetes mellitus is a chronic disease characterized by lack of insulin production.
Immune mechanisms are implicated in the pathogenesis of Type 1 diabetes.
Canarium odontophyllum (CO) fruits and leaves have been shown to possess high antioxidant activity.
This study was conducted to evaluate the effects of CO leaves aqueous extract on the blood glucose and T lymphocyte population in the spleen of streptozotocin (STZ)-induced diabetic rats.
Nineteen male Sprague–Dawley rats were randomly divided into three groups: normal, diabetic control and CO treated diabetic groups.
Diabetes was induced by a single intraperitoneal injection of 65 mg STZ/kg body weight.
The extract of CO leaves was administered orally by force feeding daily at the dose of 300 mg/kg for 28 days.
The rats were sacrificed at the end of the study and the spleen was harvested for flow cytometry analysis.
The results showed a significant decrease in body weight of diabetic and CO treated diabetic groups compared with the normal group (p< 0.05).
The fasting blood glucose level of CO treated diabetic group was significantly lower than the diabetic group (p<0.05).
Diabetic and CO treated diabetic groups showed a significant increase in the percentage of spleen CD3+ CD4+ T lymphocytes (p< 0.05) when compared with the normal group.
However, there was no significant difference in the percentage of spleen CD3+ CD8+ T lymphocytes among all experimental groups.
The finding suggested that an aqueous extract of CO leaves has the ability to reduce blood glucose levels in diabetic rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Saari, Shafikha Mohd& Basri, Dayang Fredalina& Budin, Siti Balkis& Warif, Nur Malia Abd. 2017. Effects of Canarium odontophyllum leaves on plasma glucose and T lymphocyte population in streptozotocin-induced diabetic rats. Saudi Journal of Biological Sciences،Vol. 24, no. 2, pp.320-323.
https://search.emarefa.net/detail/BIM-776413
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Saari, Shafikha Mohd…[et al.]. Effects of Canarium odontophyllum leaves on plasma glucose and T lymphocyte population in streptozotocin-induced diabetic rats. Saudi Journal of Biological Sciences Vol. 24, no. 2 (Feb. 2017), pp.320-323.
https://search.emarefa.net/detail/BIM-776413
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Saari, Shafikha Mohd& Basri, Dayang Fredalina& Budin, Siti Balkis& Warif, Nur Malia Abd. Effects of Canarium odontophyllum leaves on plasma glucose and T lymphocyte population in streptozotocin-induced diabetic rats. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 2, pp.320-323.
https://search.emarefa.net/detail/BIM-776413
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 323
رقم السجل
BIM-776413
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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