Study of obesity associated proopiomelanocortin gene polymorphism : relation to metabolic profile and eating habits in a sample of obese Egyptian children and adolescents
المؤلفون المشاركون
Kamal, Tariq M.
Hamzah, Rasha Tarif
Muhammad, Faridah al-Baz
Amr, Nirmin H.
Mahmud, Rana A.
Yusuf, Azzah M.
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 18، العدد 1 (31 يناير/كانون الثاني 2017)، ص ص. 67-73، 7ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2017-01-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Melanocortinergic system represents a known system involved in the central regulation of body weight with the central proopiomelanocortin (POMC) neurons forming a potent anorexigenic network.
Polymorphisms in the POMC gene locus are associated with obesity phenotypes.
Aim : To assess the contribution of the POMC gene 9-bp insertional polymorphism in the susceptibility to obesity and its relation to body mass index (BMI) and adiposity-related co-morbidities in obese children and adolescents; as well as binge eating behavior.
Patients and methods: Fifty obese children and adolescents with simple obesity were screened for Binge Eating Disorder (BED) by The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), they were compared to 50 age, sex and pubertal stage-matched non obese controls.
Anthropometric measurements, blood pressure, abdominal ultrasound for fatty liver, measurement of fasting lipid profile, fasting insulin, fasting blood glucose and assessment of POMC gene 9-bp insertional polymorphism were done.
Results : Obese patients had significantly higher anthropometric measurements, blood pressure percentiles, fasting glucose, fasting insulin, homeostasis model assessment for insulin resistance (HOMA-IR) and fasting lipid profiles, and higher frequency of occurrence of non alcoholic fatty liver disease and BED.
Allelic frequencies of POMC gene 9 bp insertional polymorphism were comparable in patients and controls (p= 0.956).
Fasting insulin levels were significantly higher in the heterozygous cases having the polymorphism than in wild homozygous cases; whereas no difference was observed among the controls
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muhammad, Faridah al-Baz& Hamzah, Rasha Tarif& Amr, Nirmin H.& Yusuf, Azzah M.& Kamal, Tariq M.& Mahmud, Rana A.. 2017. Study of obesity associated proopiomelanocortin gene polymorphism : relation to metabolic profile and eating habits in a sample of obese Egyptian children and adolescents. The Egyptian Journal of Medical Human Genetics،Vol. 18, no. 1, pp.67-73.
https://search.emarefa.net/detail/BIM-777813
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kamal, Tariq M.…[et al.]. Study of obesity associated proopiomelanocortin gene polymorphism : relation to metabolic profile and eating habits in a sample of obese Egyptian children and adolescents. The Egyptian Journal of Medical Human Genetics Vol. 18, no. 1 (Jan. 2017), pp.67-73.
https://search.emarefa.net/detail/BIM-777813
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muhammad, Faridah al-Baz& Hamzah, Rasha Tarif& Amr, Nirmin H.& Yusuf, Azzah M.& Kamal, Tariq M.& Mahmud, Rana A.. Study of obesity associated proopiomelanocortin gene polymorphism : relation to metabolic profile and eating habits in a sample of obese Egyptian children and adolescents. The Egyptian Journal of Medical Human Genetics. 2017. Vol. 18, no. 1, pp.67-73.
https://search.emarefa.net/detail/BIM-777813
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 72-73
رقم السجل
BIM-777813
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر