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Study of obesity associated proopiomelanocortin gene polymorphism : relation to metabolic profile and eating habits in a sample of obese Egyptian children and adolescents
المؤلفون المشاركون
Kamal, Tariq M.
Hamzah, Rasha Tarif
Muhammad, Faridah al-Baz
Amr, Nirmin H.
Mahmud, Rana A.
Yusuf, Azzah M.
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 18، العدد 1 (31 يناير/كانون الثاني 2017)، ص ص. 67-73، 7ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2017-01-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Melanocortinergic system represents a known system involved in the central regulation of body weight with the central proopiomelanocortin (POMC) neurons forming a potent anorexigenic network.
Polymorphisms in the POMC gene locus are associated with obesity phenotypes.
Aim : To assess the contribution of the POMC gene 9-bp insertional polymorphism in the susceptibility to obesity and its relation to body mass index (BMI) and adiposity-related co-morbidities in obese children and adolescents; as well as binge eating behavior.
Patients and methods: Fifty obese children and adolescents with simple obesity were screened for Binge Eating Disorder (BED) by The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), they were compared to 50 age, sex and pubertal stage-matched non obese controls.
Anthropometric measurements, blood pressure, abdominal ultrasound for fatty liver, measurement of fasting lipid profile, fasting insulin, fasting blood glucose and assessment of POMC gene 9-bp insertional polymorphism were done.
Results : Obese patients had significantly higher anthropometric measurements, blood pressure percentiles, fasting glucose, fasting insulin, homeostasis model assessment for insulin resistance (HOMA-IR) and fasting lipid profiles, and higher frequency of occurrence of non alcoholic fatty liver disease and BED.
Allelic frequencies of POMC gene 9 bp insertional polymorphism were comparable in patients and controls (p= 0.956).
Fasting insulin levels were significantly higher in the heterozygous cases having the polymorphism than in wild homozygous cases; whereas no difference was observed among the controls
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muhammad, Faridah al-Baz& Hamzah, Rasha Tarif& Amr, Nirmin H.& Yusuf, Azzah M.& Kamal, Tariq M.& Mahmud, Rana A.. 2017. Study of obesity associated proopiomelanocortin gene polymorphism : relation to metabolic profile and eating habits in a sample of obese Egyptian children and adolescents. The Egyptian Journal of Medical Human Genetics،Vol. 18, no. 1, pp.67-73.
https://search.emarefa.net/detail/BIM-777813
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kamal, Tariq M.…[et al.]. Study of obesity associated proopiomelanocortin gene polymorphism : relation to metabolic profile and eating habits in a sample of obese Egyptian children and adolescents. The Egyptian Journal of Medical Human Genetics Vol. 18, no. 1 (Jan. 2017), pp.67-73.
https://search.emarefa.net/detail/BIM-777813
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muhammad, Faridah al-Baz& Hamzah, Rasha Tarif& Amr, Nirmin H.& Yusuf, Azzah M.& Kamal, Tariq M.& Mahmud, Rana A.. Study of obesity associated proopiomelanocortin gene polymorphism : relation to metabolic profile and eating habits in a sample of obese Egyptian children and adolescents. The Egyptian Journal of Medical Human Genetics. 2017. Vol. 18, no. 1, pp.67-73.
https://search.emarefa.net/detail/BIM-777813
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 72-73
رقم السجل
BIM-777813
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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