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Null association of maternal MTHFR A1298C polymorphism with down syndrome pregnancy : an updated meta-analysis
المؤلفون المشاركون
Yadav, Upendra
Rai, Vandana
Kumar, Pradeep
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 18، العدد 1 (31 يناير/كانون الثاني 2017)، ص ص. 9-18، 10ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2017-01-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme of folate/homocysteine pathway and is essential for DNA synthesis and methylation.
MTHFR gene polymorphisms have been reported as risk factors for congenital defects and several metabolic and neurological disorders.
Several studies have investigated an association between maternal MTHFR A1298C polymorphism and Down syndrome (DS) child.
However, results have been inconclusive.
Aim : A meta-analysis of published case–control studies up to December, 2015 was performed to investigate this association.
Methods : Electronic databases were searched for case–control studies and odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the association.
Total twenty-one case–control studies with 2004 cases and 2523 controls were included in the present meta-analysis.
Results : Results of meta-analysis showed a significant association between maternal A1298C polymorphism and DS pregnancy with homozygote model (CC vs.
AA: OR= 1.26, 95% CI= 1.01–1.58, p=0.04), but no such association was found in any other genetic models (C vs.
A: OR =1.07, 95% CI= 0.93–1.23, p=0.32; CC + AC vs.
AA: OR =1.08, 95% CI= 0.96– 1.23, p=0.18; CC vs.
AC+ AA: OR = 1.11, 95% CI= 0.90–1.36, p=0.30; AC vs.
AA: OR =1.06, 95% CI= 0.93–1.21, p= 0.34).
Conclusion: Subgroup and sensitivity analysis results showed that this polymorphism is a risk factor for DS pregnancy in Asian populations but not in Caucasian population as well as in overall meta-analysis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rai, Vandana& Yadav, Upendra& Kumar, Pradeep. 2017. Null association of maternal MTHFR A1298C polymorphism with down syndrome pregnancy : an updated meta-analysis. The Egyptian Journal of Medical Human Genetics،Vol. 18, no. 1, pp.9-18.
https://search.emarefa.net/detail/BIM-777827
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rai, Vandana…[et al.]. Null association of maternal MTHFR A1298C polymorphism with down syndrome pregnancy : an updated meta-analysis. The Egyptian Journal of Medical Human Genetics Vol. 18, no. 1 (Jan. 2017), pp.9-18.
https://search.emarefa.net/detail/BIM-777827
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rai, Vandana& Yadav, Upendra& Kumar, Pradeep. Null association of maternal MTHFR A1298C polymorphism with down syndrome pregnancy : an updated meta-analysis. The Egyptian Journal of Medical Human Genetics. 2017. Vol. 18, no. 1, pp.9-18.
https://search.emarefa.net/detail/BIM-777827
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 16-18
رقم السجل
BIM-777827
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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