Resveratrol, an antioxidant, protects spinal cord injury in rats by suppressing MAPK pathway
المؤلفون المشاركون
Wang, Longqiang
Fu, Song
Lv, Renhua
Hou, Haitao
Liu, Haijun
Shao, Shize
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 25، العدد 2 (28 فبراير/شباط 2018)، ص ص. 259-266، 8ص.
الناشر
تاريخ النشر
2018-02-28
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Resveratrol, a polyphenol found in various plants, including grapes, plums and peanuts has shown various medIRInal properties, including antioxidant, protection of cardiovascular disease and cancer risk.
However, the effects of resveratrol on spinal cord reperfusion injury have not been investigated.
Hence, the present study was designed to evaluate the effect of resveratrol on nitric oxide synthase (iNOS) / p38MAPK signaling pathway and to elucidate its regulating effect on the protection of spinal cord injury.
Spinal cord ischemia–reperfusion injury (IRI) was performed by the infrarenal abdominal aorta with mini aneurysm clip model.
The expressions of iNOS and p38MAPK and the levels of biochemical parameters, including nitrite / nitrate, malondialdehyde (MDA), advanced oxidation products (AOPP), reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) were measured in control and experimental groups.
IRI-induced rats treated with 10 mg / kg resveratrol protected spinal cord from ischemia injury as supported by improved biological parameters measured in spinal cord tissue homogenates.
The resveratrol treatment significantly decreased the levels of plasma nitrite / nitrate, iNOS mRNA and protein expressions and phosphorylation of p38MAPK in IRI-induced rats.
Further, IRI-produced free radicals were reduced by resveratrol treatment by increasing enzymatic and non-enzymatic antioxidant levels such as GSH, SOD and CAT.
Taken together, administration of resveratrol protects the damage caused by spinal cord ischemia with potential mechanism of suppressing the activation of iNOS / p38MAPK pathway and subsequent reduction of oxidative stress due to IRI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fu, Song& Lv, Renhua& Wang, Longqiang& Hou, Haitao& Liu, Haijun& Shao, Shize. 2018. Resveratrol, an antioxidant, protects spinal cord injury in rats by suppressing MAPK pathway. Saudi Journal of Biological Sciences،Vol. 25, no. 2, pp.259-266.
https://search.emarefa.net/detail/BIM-780513
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fu, Song…[et al.]. Resveratrol, an antioxidant, protects spinal cord injury in rats by suppressing MAPK pathway. Saudi Journal of Biological Sciences Vol. 25, no. 2 (Feb. 2018), pp.259-266.
https://search.emarefa.net/detail/BIM-780513
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fu, Song& Lv, Renhua& Wang, Longqiang& Hou, Haitao& Liu, Haijun& Shao, Shize. Resveratrol, an antioxidant, protects spinal cord injury in rats by suppressing MAPK pathway. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 2, pp.259-266.
https://search.emarefa.net/detail/BIM-780513
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 265-266
رقم السجل
BIM-780513
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر