An enhanced topologically significant directed random walk in cancer classification using gene expression datasets

المؤلفون المشاركون

Seah, Choon Sen
Qasim, Shahrin
Fudzee, Muhammad Farhan Md
Ping, Jeffrey Mark Law Tze
Muhammad, Muhammad Saberi
Sad al-Din, Rd Ruhmat
Ismail, Muhammad Arfian

المصدر

Saudi Journal of Biological Sciences

العدد

المجلد 24، العدد 8 (31 ديسمبر/كانون الأول 2017)، ص ص. 1828-1841، 14ص.

الناشر

الجمعية السعودية لعلوم الحياة

تاريخ النشر

2017-12-31

دولة النشر

السعودية

عدد الصفحات

14

التخصصات الرئيسية

العلوم الطبيعية والحياتية (متداخلة التخصصات)

الملخص EN

Microarray technology has become one of the elementary tools for researchers to study the genome of organisms.

As the complexity and heterogeneity of cancer is being increasingly appreciated through genomic analysis, cancerous classification is an emerging important trend.

Significant directed random walk is proposed as one of the cancerous classification approach which have higher sensitivity of risk gene prediction and higher accuracy of cancer classification.

In this paper, the methodology and material used for the experiment are presented.

Tuning parameter selection method and weight as parameter are applied in proposed approach.

Gene expression dataset is used as the input datasets while pathway dataset is used to build a directed graph, as reference datasets, to complete the bias process in random walk approach.

In addition, we demonstrate that our approach can improve sensitive predictions with higher accuracy and biological meaningful classification result.

Comparison result takes place between significant directed random walk and directed random walk to show the improvement in term of sensitivity of prediction and accuracy of cancer classification.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Seah, Choon Sen& Qasim, Shahrin& Fudzee, Muhammad Farhan Md& Ping, Jeffrey Mark Law Tze& Muhammad, Muhammad Saberi& Sad al-Din, Rd Ruhmat…[et al.]. 2017. An enhanced topologically significant directed random walk in cancer classification using gene expression datasets. Saudi Journal of Biological Sciences،Vol. 24, no. 8, pp.1828-1841.
https://search.emarefa.net/detail/BIM-780581

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Fudzee, Muhammad Farhan Md…[et al.]. An enhanced topologically significant directed random walk in cancer classification using gene expression datasets. Saudi Journal of Biological Sciences Vol. 24, no. 8 (Dec. 2017), pp.1828-1841.
https://search.emarefa.net/detail/BIM-780581

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Seah, Choon Sen& Qasim, Shahrin& Fudzee, Muhammad Farhan Md& Ping, Jeffrey Mark Law Tze& Muhammad, Muhammad Saberi& Sad al-Din, Rd Ruhmat…[et al.]. An enhanced topologically significant directed random walk in cancer classification using gene expression datasets. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 8, pp.1828-1841.
https://search.emarefa.net/detail/BIM-780581

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 184

رقم السجل

BIM-780581