Effect of total flavonoid in rabdosia rubescens on tolerant mice models under cerebral anoxia

المؤلفون المشاركون

Miao, Mingsan
Tian, Shuo
Kang, Le
Bai, Ming

المصدر

Saudi Journal of Biological Sciences

العدد

المجلد 24، العدد 8 (31 ديسمبر/كانون الأول 2017)، ص ص. 1798-1802، 5ص.

الناشر

الجمعية السعودية لعلوم الحياة

تاريخ النشر

2017-12-31

دولة النشر

السعودية

عدد الصفحات

5

التخصصات الرئيسية

العلوم الطبيعية والحياتية (متداخلة التخصصات)

الملخص EN

Objective : to study the protective effect of total flavonoid in rabdosia rubescens on BIT model by brain ischemic tolerance (hereinafter BIT) model of mice.

Method: BIT model is used to block bilateral common carotid arteries and to copy BIT model of mice.

After 10 min of transient ischemia for rats in preconditioning group, the mice in the nimodipine group and naoluotong capsule group were given the total flavonoid in rabdosia rubescens (300 mg / kg, 150 mg / kg, 75 mg / kg) for gavage, sham operation group, ischemia / reperfusion injury (hereinafter IRI) group and BIT group were fed with the same volume of 0.5% sodium carboxymethyl cellulose (CMC) once a day for 5 days.

After administration for 1 h on day 5 (120 h), the rats in the other groups except for the sham operation group were treated with blood flow block for 30 min and reperfusion for 22 h.

The serum NSE level were measured and the brain NO content and NOS activity changes was measured to observe the histopathological changes of brain tissue.

Results : bit models of mice and in rats were both successfully replicated.

The total flavonoid in rabdosia rubescens can decrease the mortality of mice, decrease serum NSE level, increase the content of NO and the activity of NOS in the brain tissue of mice, and improve the pathological damage of cortex and hippocampus of mice.

Conclusion : the total flavonoid in rabdosia rubescens can stimulate an endogenous protective mechanism by inducing the release of low levels of cytokines NO and NOS, which reduces the release of serum NSE, relieves the brain tissue ischemia-reperfusion injury, and further improves the protection effect of ischemic preconditioning on brain injury.

The damage of brain tissue ischemia and reperfusion, and further improve the ischemia Protective effect of preconditioning on brain injury

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Kang, Le& Miao, Mingsan& Bai, Ming& Tian, Shuo. 2017. Effect of total flavonoid in rabdosia rubescens on tolerant mice models under cerebral anoxia. Saudi Journal of Biological Sciences،Vol. 24, no. 8, pp.1798-1802.
https://search.emarefa.net/detail/BIM-780604

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Kang, Le…[et al.]. Effect of total flavonoid in rabdosia rubescens on tolerant mice models under cerebral anoxia. Saudi Journal of Biological Sciences Vol. 24, no. 8 (Dec. 2017), pp.1798-1802.
https://search.emarefa.net/detail/BIM-780604

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Kang, Le& Miao, Mingsan& Bai, Ming& Tian, Shuo. Effect of total flavonoid in rabdosia rubescens on tolerant mice models under cerebral anoxia. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 8, pp.1798-1802.
https://search.emarefa.net/detail/BIM-780604

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 1802

رقم السجل

BIM-780604