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Intervention effect of total flavonoids of ilex pubesceus on tolerant rat models under cerebral anoxia
المؤلفون المشاركون
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 24، العدد 8 (31 ديسمبر/كانون الأول 2017)، ص ص. 1871-1878، 8ص.
الناشر
تاريخ النشر
2017-12-31
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الملخص EN
Objective : To observe the intervention effect of total flavonoid of ilex pubesceus on animal models of cerebral ischemic tolerance.
Methods: A rat model of global-focal cerebral ischemic tolerance was established by blocking bilateral common carotid artery blood flow and occluding left middle cerebral artery using thread-occlusion method.
After the first operation, the Ginaton group and large-dosage, medium-dosage and small-dosage groups of total flavonoid of ilex pubesceus were given intragastric administration of corresponding drugs.
The sham-operated group, pretreatment model group and ischemia-reperfusion group were given intragastric administration of the same volume of normal saline, 1 time a day, and administrated for 4d.
At 24 h after the second operation, the neurological deficit was assessed, the whole blood viscosity, plasma viscosity, iNOS activity as well as NO level, IL-1b content and TNF-a content in the brain tissue of the rats were determined, and the morphological changes of brain tissue of the rats were observed by HE staining.
Results: All the rat models of cerebral ischemic tolerance were established successfully.
The total flavonoid of ilex pubesceus can obviously or significantly reduce the neurological deficit score, whole blood viscosity and plasma viscosity, obviously or significantly increase the NO level in the brain tissue of the rats, and significantly reduce the pathological damage of brain tissue of the rats.
But compared with the ischemia-reperfusion group, the total flavonoid of ilex pubesceus can significantly or obviously increase the iNOS activity, IL-1b content and TNF-a content in the brain tissue of the rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kang, Le& Miao, Mingsan. 2017. Intervention effect of total flavonoids of ilex pubesceus on tolerant rat models under cerebral anoxia. Saudi Journal of Biological Sciences،Vol. 24, no. 8, pp.1871-1878.
https://search.emarefa.net/detail/BIM-780611
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kang, Le& Miao, Mingsan. Intervention effect of total flavonoids of ilex pubesceus on tolerant rat models under cerebral anoxia. Saudi Journal of Biological Sciences Vol. 24, no. 8 (Dec. 2017), pp.1871-1878.
https://search.emarefa.net/detail/BIM-780611
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kang, Le& Miao, Mingsan. Intervention effect of total flavonoids of ilex pubesceus on tolerant rat models under cerebral anoxia. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 8, pp.1871-1878.
https://search.emarefa.net/detail/BIM-780611
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1878
رقم السجل
BIM-780611
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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