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ERK MAPK and PI3K AKT signal channels simultaneously activated in nerve cell and axon after facial nerve injury
المؤلفون المشاركون
Hu, Min
Sun, Zhi Gang
Ma, Jun Tao
Liu, Hua Wei
Huang, Hai Tao
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 24، العدد 8 (31 ديسمبر/كانون الأول 2017)، ص ص. 1853-1858، 6ص.
الناشر
تاريخ النشر
2017-12-31
دولة النشر
السعودية
عدد الصفحات
6
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الملخص EN
Background : the in-vitro study indicated that ERK/MAPK and PI3K/AKT signal channels may play an important role in reparative regeneration process after peripheral nerve injury.
But, relevant in-vivo study was infrequent.
In particular, there has been no report on simultaneous activation of ERK/MAPK and PI3K / AKT signal channels in facial nerve cell and axon after facial nerve injury.
Results : the expression of P-ERK enhanced in nerve cells at the injury side on the 1 d after the rat facial nerve was cut and kept on a higher level until 14 d, but decreased on 28 d.
The expression of P-AKT enhanced in nerve cells at the injury side on 1 d after injury, and kept on a higher level until 28 d.
The expression of P-ERK enhanced at the near and far sections of the injured axon on 1 d, then increased gradually and reached the maximum on 7 d, but decreased on 14 d, until down to the level before the injury on 28 d.
The expression of P-AKT obviously enhanced in the injured axon on 1 d, especially in the axon of the rear section, but decreased in the axon of the rear section on 7 d, while the expression of axon in the far section increased to the maximum and kept on till 14 d.
On 28 d, the expression of P-AKT decreased in both rear and far sections of the axon.
Conclusion: The facial nerve simultaneously activated ERK/MAPK and PI3K/AKT signal channels in facial nerve cells and axons after the cut injury, but the expression levels of P-ERK and P-AKT varied as the function of the time.
In particular, they were quite different in axon of the far section.
It has been speculated that two signal channels might have different functions after nerve injury.
However, their specific regulating effects should still be testified by further studies in regenerative process of peripheral nerve injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Zhi Gang& Ma, Jun Tao& Liu, Hua Wei& Hu, Min& Huang, Hai Tao. 2017. ERK MAPK and PI3K AKT signal channels simultaneously activated in nerve cell and axon after facial nerve injury. Saudi Journal of Biological Sciences،Vol. 24, no. 8, pp.1853-1858.
https://search.emarefa.net/detail/BIM-780612
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Zhi Gang…[et al.]. ERK MAPK and PI3K AKT signal channels simultaneously activated in nerve cell and axon after facial nerve injury. Saudi Journal of Biological Sciences Vol. 24, no. 8 (Dec. 2017), pp.1853-1858.
https://search.emarefa.net/detail/BIM-780612
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Zhi Gang& Ma, Jun Tao& Liu, Hua Wei& Hu, Min& Huang, Hai Tao. ERK MAPK and PI3K AKT signal channels simultaneously activated in nerve cell and axon after facial nerve injury. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 8, pp.1853-1858.
https://search.emarefa.net/detail/BIM-780612
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1857-1858
رقم السجل
BIM-780612
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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