Influence of crocetin on high-cholesterol diet induced atherosclerosis in rats via anti-oxidant activity together with inhibition of inflammatory response and p38 MAPK signaling pathway

المؤلفون المشاركون

Diao, Shu Ling
Sun, Jing Wu
Ma, Bao Xin
Li, Xiao Mei
Wang, Dong

المصدر

Saudi Journal of Biological Sciences

العدد

المجلد 25، العدد 3 (31 مارس/آذار 2018)، ص ص. 493-499، 7ص.

الناشر

الجمعية السعودية لعلوم الحياة

تاريخ النشر

2018-03-31

دولة النشر

السعودية

عدد الصفحات

7

التخصصات الرئيسية

الأحياء

الموضوعات

الملخص EN

The present study aimed to investigate the effect and possible mechanism of action of crocetin on the high cholesterol diet (HCD) induced atherosclerosis rat.

The Wistar rats were used in the current investigation.

The rats were divided into following group, Group I : control, Group II : HCD induced AS, Group III: AS + crocetin (25 mg / kg), Group IV : AS + crocetin (50 mg / kg) and Group V : AS +Simvastatin, respectively.

AS was induced in the rats using the vitamin D3 and HCD.

The rats received the pre-determined treatment for the 10 weeks.

After the study period, the level of lipid profile, malonaldehyde (MDA) and uperoxide dismutase (SOD) were also estimated.

The proinflammatory cytokines viz., tumor necrosis factor (TNF)-a and interleukin (IL)-6 were scrutinized using the ELISA kits.

We also estimated the expression of phosphorylated p38 (p-p38) MAPK using the Western blot techniques.

The results revealed that the AS was successfully induced in the rats.

The AS control group rats showed the modulated level of lipid profile, and decreased the level of the SOD and boost the level of the MDA ascompared with the normal control.

However, crocetin thrived in enhancing the lipid profile toward the standard value in the normal control group rats.

The crocetin and simvastatin group rats significantly inhibited the expression of the p-p38 MAPK as compared to the AS group rats.

In conclusion, the current investigation revealed that the crocetin reduced the HCD induced dyslipidemia in the Wistar rats, the possible mechanism of action may be connected to the antioxidative, down regulating of p-p38 MAPK and antiinflammatory effect by crocetin.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Diao, Shu Ling& Sun, Jing Wu& Ma, Bao Xin& Li, Xiao Mei& Wang, Dong. 2018. Influence of crocetin on high-cholesterol diet induced atherosclerosis in rats via anti-oxidant activity together with inhibition of inflammatory response and p38 MAPK signaling pathway. Saudi Journal of Biological Sciences،Vol. 25, no. 3, pp.493-499.
https://search.emarefa.net/detail/BIM-780685

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wang, Dong…[et al.]. Influence of crocetin on high-cholesterol diet induced atherosclerosis in rats via anti-oxidant activity together with inhibition of inflammatory response and p38 MAPK signaling pathway. Saudi Journal of Biological Sciences Vol. 25, no. 3 (Mar. 2018), pp.493-499.
https://search.emarefa.net/detail/BIM-780685

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Diao, Shu Ling& Sun, Jing Wu& Ma, Bao Xin& Li, Xiao Mei& Wang, Dong. Influence of crocetin on high-cholesterol diet induced atherosclerosis in rats via anti-oxidant activity together with inhibition of inflammatory response and p38 MAPK signaling pathway. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 3, pp.493-499.
https://search.emarefa.net/detail/BIM-780685

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 498-499

رقم السجل

BIM-780685