![](/images/graphics-bg.png)
L-arginine accentuates sickness behavior induced by lipopolysaccharides in male albino rats
العناوين الأخرى
إل-آرجينين يبرز السلوك المرضي المستحدث بواسطة عديدات السكر الدهنية في ذكور الفئران البيضاء
المؤلف
المصدر
Assiut Veterinary Medical Journal
العدد
المجلد 63، العدد 152 (31 يناير/كانون الثاني 2017)، ص ص. 117-124، 8ص.
الناشر
تاريخ النشر
2017-01-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الملخص EN
Sickness behavior is a behavioral changes occurring soon after the onset of infection, trauma, and inflammatory processes.
In animals, systemic administration of lipopolysaccharide (LPS) induces a characteristic set of responses that has been termed "sickness behavior".
Recent empirical results have provided an evidence that inhibition of the production of nitric oxide (NO) from L-arginine (L-Arg) by NG-nitro-L-arginine methyl ester (L-NAME) accentuated LPS-induced sickness behaviors in male rats.
The impact of the L-Arg on LPS-induced sickness behaviors in rats has not yet been tested.
To evaluate the possible participation of L-Arg/NO pathway in LPS-induced sickness behaviors, rats were tested in the open field test using LE8811 Actimeter PanLAB device.
Rats were weighed, randomly divided into 4 groups (five rats in each group), and intraperitoneally injected as follow: Control group (saline, 0.1ml/100g b.wt), LPS group (LPS, 1 mg/kg b.wt), L-arginine group (L-Arg, 10 mg/kg b.wt, for 7 days), and LPS+L-arginine group (L-Arg, 10 mg/kg b.wt, for 7 days then once injected with LPS, 1mg/kg).
Locomotor and behavioral activity levels of the animals were evaluated to measure horizontal activity (units), vertical activity (units), stereotype (units) movements, total distance traveled (cm), and average velocity.
LPS decreased locomotor and behavioral activities but not reaching significance.
In contrast, the pretreatment with L-Arg was associated with an increase in locomotor and behavioral activities but also not reaching significance.
Interestingly, pretreatment with L-Arg of LPS-treated rats accentuated locomotor and behavioral changes induced by LPS.
In conclusion, the results of this study support the hypothesized relationship between NO synthesis and modulation of sickness behaviors and suggest that NO may has a dual role in the modulation of sickness behaviors depending on intensity and stage of inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Imbarak, Hamdi Atitu Muhammad. 2017. L-arginine accentuates sickness behavior induced by lipopolysaccharides in male albino rats. Assiut Veterinary Medical Journal،Vol. 63, no. 152, pp.117-124.
https://search.emarefa.net/detail/BIM-781039
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Imbarak, Hamdi Atitu Muhammad. L-arginine accentuates sickness behavior induced by lipopolysaccharides in male albino rats. Assiut Veterinary Medical Journal Vol. 63, no. 152 (Jan. 2017), pp.117-124.
https://search.emarefa.net/detail/BIM-781039
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Imbarak, Hamdi Atitu Muhammad. L-arginine accentuates sickness behavior induced by lipopolysaccharides in male albino rats. Assiut Veterinary Medical Journal. 2017. Vol. 63, no. 152, pp.117-124.
https://search.emarefa.net/detail/BIM-781039
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 123-124
رقم السجل
BIM-781039
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)