Synthesis and biological evaluation of pyrimidinyl sulphonamide derivatives as promising class of antitubercular agents

الملخص EN

small library of compounds are synthesized and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37RV.

Two compounds, -[(20,40-dinitrophenyl) sulphonyl]-4-(p-aminophenylsulphonylamino)-6-(20-chlorophenyl)-pyrimidine-5-carboxamide Fb and 2-hydrazino-4-(p-aminophenylsulphonylamino)-6-(20-chlorophenyl)-pyrimidine-5-carboxamide Db were found to be the most active compounds in vitro with MIC of 0.02 lg/mL against MTB and were more potent compared to isoniazid (MIC: 0.03 lg/mL).