Efficacy of Mastoparan-AF alone and in combination with clinically used antibiotics on nosocomial multidrug-resistant Acinetobacter baumannii
المؤلفون المشاركون
Lin, Chun Hsien
Lee, Mong Chuan
Lee, Hsien Ming
Chang, Sam Min
Tu, Wu Chun
Lin, Chuen Fu
Tzen, Jason T. C.
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 24، العدد 5 (31 يوليو/تموز 2017)، ص ص. 1023-1029، 7ص.
الناشر
تاريخ النشر
2017-07-31
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Emergence of multidrug-resistant Acinetobacter baumannii (MDRAB) has become a critical clinical problem worldwide and limited therapeutic options for infectious diseases caused by MDRAB.
Therefore, there is an urgent need for the development of new antimicrobial agents or alternative therapy to combat MDRAB infection.
The aim of this study was to investigate effects of Mastoparan-AF (MP-AF), an amphipathic peptide isolated from the hornet venom of Vespa affinis with broad-spectrum antimicrobial activity, on MDRAB.
As compared with clinical used antibiotics, MP-AF exhibited potent antimicrobial activity at 2–16 lg/ml against the reference strain A.
baumannii ATCC 15151 and seven MDRAB clinical isolates, especially the colistin-resistant MDRAB, E0158.
The synergistic antimicrobial combination study revealed that MP-AF acted synergistically with specific antibiotics, e.g., ciprofloxacin, trimethoprim/sulfamethoxazole (SXT) or colistin against some isolates of the MDRAB.
It was noteworthy when MP-AF combined with SXT exhibited synergistic activity against all SXT-resistant MDRAB isolates.
The synergistic combination of MP-AF and antibiotics could reduce the dosage recommended of each antimicrobial agent and improve the safety of medications with ignorable adverse effects, such as colistin with nephrotoxicity in therapeutic dose.
Furthermore, MP-AF combined with antibiotics with different antimicrobial mechanisms could reduce selective pressure of antibiotics on bacteria and prevent the emergence of antimicrobial-resistant strains.
Importantly, we are the first finding that MP-AF could make MDRAB from the original non-susceptibility to SXT become sensitivity.
In conclusion, MP-AF alone or in combination with other antibiotics, especially SXT, is a potential candidate against MDRAB infection in clinical medicine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Chun Hsien& Lee, Mong Chuan& Tzen, Jason T. C.& Lee, Hsien Ming& Chang, Sam Min& Tu, Wu Chun…[et al.]. 2017. Efficacy of Mastoparan-AF alone and in combination with clinically used antibiotics on nosocomial multidrug-resistant Acinetobacter baumannii. Saudi Journal of Biological Sciences،Vol. 24, no. 5, pp.1023-1029.
https://search.emarefa.net/detail/BIM-781957
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Chun Hsien…[et al.]. Efficacy of Mastoparan-AF alone and in combination with clinically used antibiotics on nosocomial multidrug-resistant Acinetobacter baumannii. Saudi Journal of Biological Sciences Vol. 24, no. 5 (Jul. 2017), pp.1023-1029.
https://search.emarefa.net/detail/BIM-781957
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Chun Hsien& Lee, Mong Chuan& Tzen, Jason T. C.& Lee, Hsien Ming& Chang, Sam Min& Tu, Wu Chun…[et al.]. Efficacy of Mastoparan-AF alone and in combination with clinically used antibiotics on nosocomial multidrug-resistant Acinetobacter baumannii. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 5, pp.1023-1029.
https://search.emarefa.net/detail/BIM-781957
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1028-1029
رقم السجل
BIM-781957
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر