Amberlite IRA-400 Cl resin catalyzed synthesis of secondary amines and transformation into N-((1Hindol-3-yl)‎ (heteroaryl)‎ methyl)‎-N-heteroaryl benzenamines and bis-indoles via multicomponent reaction

الملخص EN

A one-pot Amberlite IRA-400 Cl resin catalyzed the in-situ generation of imines from various aldehydes and primary amines followed by reduction with sodium borohydride affording corresponding secondary amines.

The secondary amines thus obtained were utilized for the IRA400 Cl resin catalyzed multicomponent synthesis of 3-aminoalkylated indoles using a number of aldehydes and indole.

Mild condition, easy work-up, and environmentally benign nature of the synthetic strategy make it both practical and attractive.