Changes in the NFkB and E-cadherin expression are associated to diabetic nephropathy in Psammomys obesus

المؤلفون المشاركون

Aroune, Djamila
Labdiri, Farid
Leboucher, Sophie
Maouche, Boubekeur
Marco, Sergio
al-Awfi, Sulaymah

المصدر

Saudi Journal of Biological Sciences

العدد

المجلد 24، العدد 4 (31 مايو/أيار 2017)، ص ص. 843-850، 8ص.

الناشر

الجمعية السعودية لعلوم الحياة

تاريخ النشر

2017-05-31

دولة النشر

السعودية

عدد الصفحات

8

التخصصات الرئيسية

علم الحيوان
الطب البشري

الموضوعات

الملخص EN

Diabetes mellitus is a major leading cause of end-stage renal failure, characterized by kidney inflammation and glomerular dysfunction, in worldwide.

Kidney inflammation is associated to modifications in the expression levels of pro-inflammatory molecules, such as nuclear factor-jB (NFjB) and adhesion molecules, such as E-cadherin, leading to glomerular dysfunction.

However, the relationships between these two processes in human diabetic nephropathy remain an open question.

Since Psammomys obesus is an ideal animal model to study diabetes mellitus temporal evolution, we have used this model to study the correlation between kidney structural changes and modification on the expression levels of NFjB and E-cadherin over time.

We have demonstrated that, after induction of diabetes metillus with a high energy diet (HED), P.

obesus develops the characteristic symptoms of human disease.

In detail, at the third month nuclear factor NFjB is expressed in the kidney of diabetic P.

obesus and structural renal changes, such as mesangial expansion or interstitial fibrosis, are detectable; at 6 months, thickening of glomerular basement membrane, glomerular sclerosis, and tubular atrophy occurs; at 9 months, symptoms of the final stages of the disease, such as down expression of E-cadherin, happens.

As a result of these observations we proposed that NFjB activation and E-cadherin down-expression are interlinked on diabetic kidney disease (DKD).

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Aroune, Djamila& Labdiri, Farid& Leboucher, Sophie& Maouche, Boubekeur& Marco, Sergio& al-Awfi, Sulaymah. 2017. Changes in the NFkB and E-cadherin expression are associated to diabetic nephropathy in Psammomys obesus. Saudi Journal of Biological Sciences،Vol. 24, no. 4, pp.843-850.
https://search.emarefa.net/detail/BIM-782314

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Aroune, Djamila…[et al.]. Changes in the NFkB and E-cadherin expression are associated to diabetic nephropathy in Psammomys obesus. Saudi Journal of Biological Sciences Vol. 24, no. 4 (May. 2017), pp.843-850.
https://search.emarefa.net/detail/BIM-782314

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Aroune, Djamila& Labdiri, Farid& Leboucher, Sophie& Maouche, Boubekeur& Marco, Sergio& al-Awfi, Sulaymah. Changes in the NFkB and E-cadherin expression are associated to diabetic nephropathy in Psammomys obesus. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 4, pp.843-850.
https://search.emarefa.net/detail/BIM-782314

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 849-850

رقم السجل

BIM-782314