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Protective effects of fennel oil extract against sodium valproate-induced hepatorenal damage in albino rats
المؤلف
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 24، العدد 4 (31 مايو/أيار 2017)، ص ص. 915-924، 10ص.
الناشر
تاريخ النشر
2017-05-31
دولة النشر
السعودية
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
Foeniculum vulgare (Apiaceae) is commonly known as fennel.
This herb is well-known worldwide and traditionally used as curative herbal therapy for the treatment of epileptic disease, seizurescarminative, digestive, lactogogue, diuretic, treating respiratory and gastrointestinal disorders.
The aim of present study is to investigate the possible effect of fennel oil against the toxicity of Sodium-Valproic (SVP) in albino rats.
In order to assess the protection of fennel oil on SVP induced hepato- and nephro-toxicity, male albino rats were treated with 1 ml/kg b.w fennel oil 3 days/week for 6 weeks.
The biochemical analyses of hepatic enzymes were evaluated by estimating blood biomarkers of liver and renal damage along with histological examination.
The results obtained from this work showed that treating animals with SVP lead to many histopathological alterations in the liver and kidney tissues.
The effect appeared in the liver tissue include leukocyte infiltrations, cytoplasmic vacuolization of the hepatocytes, fatty degeneration and congestion of blood vessels.
This commonly used chemical (SVP) caused some unwanted effects on the kidney cortex which histologically observed as degeneration in renal tubules, atrophy of the glomeruli and edema.
Biochemical results also revealed an abnormal increase in the enzyme level of AST, SAT, ALP, bilirubin, creatinine and urea-nitrogen, with a noticed decrease in total protein content.
However, the results of treated rats with SVP plus fennel oil showed some positive histopathological changes in both the liver and kidney tissues.
These results have confirmed that fennel oil has positive effects on the histological structure of the liver and kidney and the biochemical levels of AST, ALT, ALP, bilirubin, total proteins, creatinine and urea.
It is concluded that fennel oil has various pharmacological properties including antioxidant, anti-cancer activity, anti-inflammatory.
These valu-able effects might be due to the presence of aromatic compounds trans-anethole.
This useful properties of fennel plant could be due to its antioxidant activity that prevents the toxicity of SVP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Amudi, Wail M.. 2017. Protective effects of fennel oil extract against sodium valproate-induced hepatorenal damage in albino rats. Saudi Journal of Biological Sciences،Vol. 24, no. 4, pp.915-924.
https://search.emarefa.net/detail/BIM-782327
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Amudi, Wail M.. Protective effects of fennel oil extract against sodium valproate-induced hepatorenal damage in albino rats. Saudi Journal of Biological Sciences Vol. 24, no. 4 (May. 2017), pp.915-924.
https://search.emarefa.net/detail/BIM-782327
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Amudi, Wail M.. Protective effects of fennel oil extract against sodium valproate-induced hepatorenal damage in albino rats. Saudi Journal of Biological Sciences. 2017. Vol. 24, no. 4, pp.915-924.
https://search.emarefa.net/detail/BIM-782327
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 922-924
رقم السجل
BIM-782327
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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