Effectiveness and safety of cefpodoxime in upper respiratory tract infections in adult Egyptian population a report from the Egyptian STAR registry
المؤلف
المصدر
Egyptian Journal of Ear, Nose, Throat and Allied Sciences
العدد
المجلد 18، العدد 2 (31 يوليو/تموز 2017)، ص ص. 131-135، 5ص.
الناشر
الجمعية المصرية للأذن و الأنف و الحنجرة و العلوم المشتركة
تاريخ النشر
2017-07-31
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Cefpodoxime is a broad spectrum third generation cephalosporin with antibacterial activity similar to parenteral cephalosporins.
Active against Gram-negative and -positive bacteria, empirical treatment with cefpodoxime is recommended for a wide range of community-acquired infections.
We assessed the efficacy of cefpodoxime for the treatment of upper respiratory tract infections (URTI) in Egyptian adults, and evaluated its safety in daily practice.
Methods : This prospective, observational, multicentre study recruited adult patients, presenting with acute maxillary sinusitis and tonsilopharyngitis, prescribed 200 mg/day cefpodoxime for 5–10 days by their physicians decision.
Effectiveness, defined as the proportion of patients exhibiting a complete recovery of clinical symptoms for acute sinusitis and tonsilopharyngitis, was assessed.
Safety was evaluated by measuring the prevalence and severity of adverse events (AEs).
Results : A total of 1425 adult patients were recruited from 134 centers across Egypt.
Significant reductions in URTI-related signs and symptoms were observed in subjects prescribed cefpodoxime for a mean 5.87 ± 1.73 days.
An 83.3% cure rate and a 16.2% improvement rate were noted for both acute maxillary sinusitis and tonsilopharyngitis patients.
Superior outcomes were observed in patients with acute tonsilopharyngitis compared to the acute maxillary sinusitis cohort (86.3% and 77.4%, respectively; p < 0.001).
AEs were reported by 12 (0.8%) participants.
All AEs were mild to moderate in intensity; none were serious and all were recovered.
Conclusions : High cure rates for acute maxillary sinusitis and acute tonsilopharyngitis, and a favorable safety and tolerability profile were noted following treatment with cefpodoxime.
Thus, cefpodoxime seems to be effective as empirical treatment in adult Egyptian patients with acute UTRIs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Hamid, Usamah. 2017. Effectiveness and safety of cefpodoxime in upper respiratory tract infections in adult Egyptian population a report from the Egyptian STAR registry. Egyptian Journal of Ear, Nose, Throat and Allied Sciences،Vol. 18, no. 2, pp.131-135.
https://search.emarefa.net/detail/BIM-783183
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Hamid, Usamah. Effectiveness and safety of cefpodoxime in upper respiratory tract infections in adult Egyptian population a report from the Egyptian STAR registry. Egyptian Journal of Ear, Nose, Throat and Allied Sciences Vol. 18, no. 2 (Jul. 2017), pp.131-135.
https://search.emarefa.net/detail/BIM-783183
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Hamid, Usamah. Effectiveness and safety of cefpodoxime in upper respiratory tract infections in adult Egyptian population a report from the Egyptian STAR registry. Egyptian Journal of Ear, Nose, Throat and Allied Sciences. 2017. Vol. 18, no. 2, pp.131-135.
https://search.emarefa.net/detail/BIM-783183
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 135
رقم السجل
BIM-783183
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر