Biliary atresia recent insight
المؤلفون المشاركون
Ghazi, Rami Muhammad
Adawi, Nirmin M.
Khidr, Muhammad Ahmad
Tahun, Muhammad Mustafa
المصدر
Egyptian Pediatric Association Gazette
العدد
المجلد 66، العدد 1 (31 مارس/آذار 2018)، ص ص. 1-8، 8ص.
الناشر
تاريخ النشر
2018-03-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Biliary atresia (BA) is a rare disease characterized by ascending obstruction of bile ducts that exclusively affects newborn infants.
The etiology of the disease is not known.
BA is considered to be a phenotype resulting from several pathogenic processes leading to obstruction of the biliary tree.
It usually presents shortly after birth, characterized by persistent jaundice, hepatosplenomegaly, clay-colored stool, and dark urine.
It affects both the extra-hepatic biliary ducts (EHBDs) and the intra-hepatic biliary system (IHBDs), but the former is more severely affected.
Diagnosis of BA is a great challenge and must be achieved as early as possible to delay progression to cirrhosis.
Laboratory tests reveal direct hyperbilirubinemia and, variable levels of transaminases, gamma-glutamyl transpeptidase (GGT), and alkaline phosphatase (ALP), which overlap significantly with other causes of neonatal cholestasis.
The intraoperative cholangiogram is considered the gold standard for the diagnosis of BA and is performed routinely in many institutions.
BA can be divided into correctable and non-correctable types; the former accounts for (10– 15%) of cases, in which the proximal common hepatic duct is patent, allowing primary anastomosis of the EHBDs to the bowel.
All patients are subjected to identical surgical and medical treatments; consisting of Kasai portoenterostomy (KPE), which entails removal of the atretic extra-hepatic tissue and a Roux-en-Y jejunal loop anastomosed to the hepatic hilum.
Kasai portoenterstomy is considered a transition to liver transplantation, as the pathology may be still ongoing.
BA is the most frequent indication for liver transplantation in infants, which is the only treatment that can definitively arrest the natural disease course.
In conclusion: BA is a serious liver disease that needs to be further studied, and awareness of BA should be increased among the public and health care workers to prevent the complications of this disease
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ghazi, Rami Muhammad& Adawi, Nirmin M.& Khidr, Muhammad Ahmad& Tahun, Muhammad Mustafa. 2018. Biliary atresia recent insight. Egyptian Pediatric Association Gazette،Vol. 66, no. 1, pp.1-8.
https://search.emarefa.net/detail/BIM-783210
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ghazi, Rami Muhammad…[et al.]. Biliary atresia recent insight. Egyptian Pediatric Association Gazette Vol. 66, no. 1 (Mar. 2018), pp.1-8.
https://search.emarefa.net/detail/BIM-783210
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ghazi, Rami Muhammad& Adawi, Nirmin M.& Khidr, Muhammad Ahmad& Tahun, Muhammad Mustafa. Biliary atresia recent insight. Egyptian Pediatric Association Gazette. 2018. Vol. 66, no. 1, pp.1-8.
https://search.emarefa.net/detail/BIM-783210
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 6-8
رقم السجل
BIM-783210
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر