Downregulation of caspase 8 in a group of Iranian breast cancer patients : a pilot study
المؤلفون المشاركون
Pasdar, Ali Rida
Aghababazadeh, Masumah
Dorraki, Najmah
Javan, Fahimah Afzal
Gharib, Masumah
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 29، العدد 4 (31 ديسمبر/كانون الأول 2017)، ص ص. 191-195، 5ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2017-12-31
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Purpose: It is now well known that evading apoptosis, as a cancer hallmark, can lead to tumour initiation, progression and metastasis.
As a result of genome wide association studies, an initiator protease in this pathway, caspase 8 (CASP8), has been found to be an important gene regarding breast cancer susceptibility.
The alterations of the expression of this gene have been reported in breast cancer cell lines.
Given that in previous studies expression analysis of this gene had only been done in breast cancer cell lines, in this study we aimed to evaluate the expression of this gene in breast cancer tissues versus adjacent normal tissues, using real-time quantitative method.
Methods: Caspase 8 mRNA expression was quantified using comparative RT-qPCR in 27 fresh frozen breast tumours and 27 adjacent normal tissues.
Moreover, relationship between the expression changes of CASP8 in tumour tissue and various clinical and pathological features were evaluated in an Iranian population.
Results: The present study showed that expression of CASP8 was significantly reduced in tumour tissues compared to neighbouring normal tissues (p = .004).
CASP8 expression was significantly correlated with the status of hormone receptors (ER and PR).
Conclusion: To the best of our knowledge, this study is the first report on reduced expression of CASP8 in breast cancer versus adjacent normal tissues.
Our data support previous results obtained from cell lines and therefore highlights the seminal role of the induction of CASP8 expression, as a novel therapeutic approach, in order to sensitize tumour cells to apoptotic stimuli
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Aghababazadeh, Masumah& Dorraki, Najmah& Javan, Fahimah Afzal& Fattahi, Asya Sadat& Gharib, Masumah& Pasdar, Ali Rida. 2017. Downregulation of caspase 8 in a group of Iranian breast cancer patients : a pilot study. Journal of the Egyptian National Cancer Institute،Vol. 29, no. 4, pp.191-195.
https://search.emarefa.net/detail/BIM-783276
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Aghababazadeh, Masumah…[et al.]. Downregulation of caspase 8 in a group of Iranian breast cancer patients : a pilot study. Journal of the Egyptian National Cancer Institute Vol. 29, no. 4 (Dec. 2017), pp.191-195.
https://search.emarefa.net/detail/BIM-783276
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Aghababazadeh, Masumah& Dorraki, Najmah& Javan, Fahimah Afzal& Fattahi, Asya Sadat& Gharib, Masumah& Pasdar, Ali Rida. Downregulation of caspase 8 in a group of Iranian breast cancer patients : a pilot study. Journal of the Egyptian National Cancer Institute. 2017. Vol. 29, no. 4, pp.191-195.
https://search.emarefa.net/detail/BIM-783276
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 194-195
رقم السجل
BIM-783276
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر