Association between interleukin-18 promoter polymorphisms and risk of ischemic stroke : a case-control study
المؤلفون المشاركون
Awad, Ashraf
Bakr, Nuha M.
Hashim, Nuha A.
Sarhan, Abd Allah al-Mamun
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 19، العدد 1 (31 يناير/كانون الثاني 2018)، ص ص. 13-18، 6ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2018-01-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
ackground : Ischemic stroke (IS) is one of the main causes of death worldwide.
It is worthy to attempt to identify genes that acts as risk factors for IS for early prediction and primary prevention that may reduce its incidence.
Aim of the study was to determine the relation between interleukin-18 (IL-18) (607 C/A) and (137 G/C) polymorphisms and the risk of IS in Egyptian patients.
In parallel, to analyze these polymorphisms as risk factors for large-vessel versus small-vessel diseases.
Patients and methods : A total of 120 subjects (60 IS patients and 60 healthy controls) were recruited to the study.
Genotypic analysis of IL-18 promoter polymorphisms were performed using sequencespecific primers- polymerase chain reaction (SSP-PCR) method.
Results : For IL-18 (607 C/A) polymorphism, a significant higher risk of IS was related to the AA genotype (odd ratio (OR) = 5.38, P = 0.004,) and A allele (OR = 2.07, P = 0.006), than in controls.
Whereas, for IL-18 (137 G/C) polymorphism, a significant lower risk of IS was related to the GC genotype (OR = 0.17, P < 0.001) and C allele (OR = 0.37, P < 0.001) than in controls.
Moreover, both polymorphisms did not exhibit any significant differences between large vessel (LV) and small vessel (SV) disease of IS (P > 0.05).
In addition, the haplotype analysis showed non-significant differences between IS patients and controls (P > 0.05).
Conclusion : This study concludes that IL-18 607AA genotype and A allele may be risk factors to IS, whereas IL-18 137 GC genotype and C allele may be protective factors against IS in Egyptian population
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bakr, Nuha M.& Hashim, Nuha A.& Awad, Ashraf& Sarhan, Abd Allah al-Mamun. 2018. Association between interleukin-18 promoter polymorphisms and risk of ischemic stroke : a case-control study. The Egyptian Journal of Medical Human Genetics،Vol. 19, no. 1, pp.13-18.
https://search.emarefa.net/detail/BIM-783638
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bakr, Nuha M.…[et al.]. Association between interleukin-18 promoter polymorphisms and risk of ischemic stroke : a case-control study. The Egyptian Journal of Medical Human Genetics Vol. 19, no. 1 (Jan. 2018), pp.13-18.
https://search.emarefa.net/detail/BIM-783638
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bakr, Nuha M.& Hashim, Nuha A.& Awad, Ashraf& Sarhan, Abd Allah al-Mamun. Association between interleukin-18 promoter polymorphisms and risk of ischemic stroke : a case-control study. The Egyptian Journal of Medical Human Genetics. 2018. Vol. 19, no. 1, pp.13-18.
https://search.emarefa.net/detail/BIM-783638
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 17-18
رقم السجل
BIM-783638
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر