CD34 and Wnt3 expression in potentially malignant oral disorders
المؤلفون المشاركون
Muhammad, Dina Nazim
Nadir, Nuruz Hama-Rashid
Gata, Ibrahim Said
Gharib, Balqis Taha
المصدر
Journal of Baghdad College of Dentistry
العدد
المجلد 29، العدد 3 (30 سبتمبر/أيلول 2017)، ص ص. 59-67، 9ص.
الناشر
تاريخ النشر
2017-09-30
دولة النشر
العراق
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background : Potentially malignant oral disorders (PMOD) are common precursors of oral squamous cell carcinoma (OSCC).
Neoangiogenesis and signalling are important intermediate biomarkers that may govern the progression of dysplastic mucosa into carcinoma.
Aims : Evaluate the importance of CD34 and Wnt3 expression in PMOD and OSCC in relation to their clinicopathological parameters.
Settings and Design : Prospective cross-sectional study.
Materials and Methods : Immunohistochemical staining for CD34 and Wnt3 was performed for 41 samples.
These included 27 PMOD, six OSCC and eight normal gingival and alveolar mucosa.
Analysis of variance (ANOVA) and post-hoc tests were applied.
P<0.05 was considered statistically significant.
Results : CD34 expression showed a significant difference between groups (P<0.05).
CD34 expression decreased in patients who had PMODs, and it was seen to correlate with clinical staging in OSCC patients.
The alveolar epithelia had lower microvessel density (MVD) (9.3±.88) than the gingiva (17.47±5.09) (P<0.05), whereas the lichen planus without dysplasia had lower MVD (8.85±3.95) than both the gingiva and the dysplastic epithelia (14.46±3.89) (P<0.05).
On the other hand, Wnt3 expression was not detected in the alveolar mucosa, but scattered perinuclear and nuclear expression in the gingival mucosa was observed.
Cytoplasmic Wnt3 expression was seen in all oral lichen planus (OLP) and some leukoplakia cases with no nuclear staining, whereas its expression in proliferative verrucous leukoplakia was only nuclear.
Furthermore, OSCC showed both cytoplasmic and nuclear expression.
Conclusion : MVD may represent a useful biomarker preceding oral cancer development.
It increases from normal mucosa to dysplasia to carcinoma.
Aberrant cytoplasmic expression of Wnt3 is detected in PMOD and OSCC.
Thus, Wnt3 may be involved in disease progression
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nadir, Nuruz Hama-Rashid& Gata, Ibrahim Said& Muhammad, Dina Nazim& Gharib, Balqis Taha. 2017. CD34 and Wnt3 expression in potentially malignant oral disorders. Journal of Baghdad College of Dentistry،Vol. 29, no. 3, pp.59-67.
https://search.emarefa.net/detail/BIM-784004
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nadir, Nuruz Hama-Rashid…[et al.]. CD34 and Wnt3 expression in potentially malignant oral disorders. Journal of Baghdad College of Dentistry Vol. 29, no. 3 (Sep. 2017), pp.59-67.
https://search.emarefa.net/detail/BIM-784004
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nadir, Nuruz Hama-Rashid& Gata, Ibrahim Said& Muhammad, Dina Nazim& Gharib, Balqis Taha. CD34 and Wnt3 expression in potentially malignant oral disorders. Journal of Baghdad College of Dentistry. 2017. Vol. 29, no. 3, pp.59-67.
https://search.emarefa.net/detail/BIM-784004
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes appendices : p. 64-67
رقم السجل
BIM-784004
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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