Atypical antiglomerular basement membranes disease with nephrotic-range proteinuria, mesangial proliferation, and membranoproliferative glomerulonephritis pattern of injury
المؤلفون المشاركون
al-Awdah, Nurah
al-Sad, Khalid O.
al-Suwaylimi, Banan
al-Suwaylimi, Ghadah
al-Hasan, al-Walid Ali
al-Sayyari, Abd Allah A.
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 28، العدد 6 (31 ديسمبر/كانون الأول 2017)، ص ص. 1397-1403، 7ص.
الناشر
تاريخ النشر
2017-12-31
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Antiglomerular basement membrane (anti-GBM) disease is an uncommon autoimmune disease characterized by the presence of IgG autoantibodies targeting the alpha-3 chain of type IV collagen.
Some of the atypical forms of the disease have been described.
Herein, we describe a case of atypical anti-GBM in a 27-year-old Saudi male who presented with lower limb edema, gross hematuria, elevated serum creatinine concentration, and nephrotic-range proteinuria.
All serology tests were negative, except for anti-GBM which was weakly positive.
Renal biopsy showed proliferative glomerulonephritis (GN) with nodular transformation of the glomerular tufts, mesangial hypercellularity (mesangial cell proliferation), segmental endocapillary hypercellularity and three incomplete cellular crescents, and recapitulating membranoproliferative GN pattern of glomerular injury.
Direct immunofluorescence microscopy demonstrated diffuse, intense linear positivity for IgG and Kappa and Lambda light chains, and compatible with anti- GBM disease.
The patient was treated with cyclophosphamide and corticosteroids in addition to therapeutic plasma exchange which resulted in mild improvement in renal function over a period of six weeks.
We emphasize the importance of recognition of atypical pathological and serological patterns of anti-GBM disease, which is crucial for proper and early diagnosis and possibly improved clinical outcome and we highlight the importance of clinicopathological correlation in cases with atypical clinical and pathological presentations
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Suwaylimi, Banan& al-Suwaylimi, Ghadah& al-Awdah, Nurah& al-Sad, Khalid O.& al-Hasan, al-Walid Ali& al-Sayyari, Abd Allah A.. 2017. Atypical antiglomerular basement membranes disease with nephrotic-range proteinuria, mesangial proliferation, and membranoproliferative glomerulonephritis pattern of injury. Saudi Journal of Kidney Diseases and Transplantation،Vol. 28, no. 6, pp.1397-1403.
https://search.emarefa.net/detail/BIM-785689
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Sayyari, Abd Allah A.…[et al.]. Atypical antiglomerular basement membranes disease with nephrotic-range proteinuria, mesangial proliferation, and membranoproliferative glomerulonephritis pattern of injury. Saudi Journal of Kidney Diseases and Transplantation Vol. 28, no. 6 (Nov. / Dec. 2017), pp.1397-1403.
https://search.emarefa.net/detail/BIM-785689
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Suwaylimi, Banan& al-Suwaylimi, Ghadah& al-Awdah, Nurah& al-Sad, Khalid O.& al-Hasan, al-Walid Ali& al-Sayyari, Abd Allah A.. Atypical antiglomerular basement membranes disease with nephrotic-range proteinuria, mesangial proliferation, and membranoproliferative glomerulonephritis pattern of injury. Saudi Journal of Kidney Diseases and Transplantation. 2017. Vol. 28, no. 6, pp.1397-1403.
https://search.emarefa.net/detail/BIM-785689
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1402-1403
رقم السجل
BIM-785689
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر