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First-line paclitaxel and cisplatin used sequentially or in combination in metastatic breast cancer : a phase II randomized study
المؤلفون المشاركون
al-Sirafi, Mustafa M.
Buhush, Wafa H.
Munir, Manar M.
Nassar, Hanan R.
Abd al-Salam, Ibrahim M.
Zayn al-Din, Ahmad A.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 30، العدد 1 (31 يناير/كانون الثاني 2018)، ص ص. 13-20، 8ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2018-01-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Introduction : Breast cancer (BC) is the commonest cancer among females worldwide.
Some patients present initially at advanced stages and more than 50% of them will develop metastasis (MBC) at some point.
Compared to single agents, combination chemotherapy produces higher response rates (RR), longer progression-free survival (PFS) than single agents.
This is associated with remarkably higher toxicities.
At the same time, overall survival (OS) is comparable.
This study aimed to compare safety and efficacy of combination and sequential chemotherapy.
Patients and Methods : Forty-six MBC patients were randomized to receive 6 cycles of the combination of paclitaxel (175 mg/m2) and cisplatin (70 mg/m2) (combination PC) or paclitaxel for 3 cycles followed by cisplatin for 3 cycles (sequential PC).
Endpoints were RR, PFS, OS and safety.
Results : Both combination and sequential PC produced similar RR (52% in both arms) and disease control rates (78.3% vs.
73.9%, p = .652).
Responses were faster in the combination arm.
Median PFS was 8.2 months in the combination compared to 5.0 months in the sequential arm (p = .064).
The median OS was 16.5 and 18.8 months in the combination and sequential arms, respectively (p = .866).
The combination was more toxic than sequential PC.
Grade 3 toxicities were higher with combination PC than to sequential PC (48% vs.
4.3%; p < .001).
Conclusion : Sequential agent chemotherapy may provide similar response rate and overall survival to combination chemotherapy with much lower toxicities.
The former can be considered the standard practice in most instances.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Sirafi, Mustafa M.& Zayn al-Din, Ahmad A.& Abd al-Salam, Ibrahim M.& Nassar, Hanan R.& Munir, Manar M.& Buhush, Wafa H.. 2018. First-line paclitaxel and cisplatin used sequentially or in combination in metastatic breast cancer : a phase II randomized study. Journal of the Egyptian National Cancer Institute،Vol. 30, no. 1, pp.13-20.
https://search.emarefa.net/detail/BIM-788949
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Sirafi, Mustafa M.…[et al.]. First-line paclitaxel and cisplatin used sequentially or in combination in metastatic breast cancer : a phase II randomized study. Journal of the Egyptian National Cancer Institute Vol. 30, no. 1 (Jan. 2018), pp.13-20.
https://search.emarefa.net/detail/BIM-788949
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Sirafi, Mustafa M.& Zayn al-Din, Ahmad A.& Abd al-Salam, Ibrahim M.& Nassar, Hanan R.& Munir, Manar M.& Buhush, Wafa H.. First-line paclitaxel and cisplatin used sequentially or in combination in metastatic breast cancer : a phase II randomized study. Journal of the Egyptian National Cancer Institute. 2018. Vol. 30, no. 1, pp.13-20.
https://search.emarefa.net/detail/BIM-788949
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 19-20
رقم السجل
BIM-788949
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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