Design, synthesis and biological evaluation of quinazolin-4 (3H)‎-one Schiff base conjugates as potential antiamoebic agents

الملخص EN

In an effort to develop novel antiamoebic scaffolds having better efficacy than the standard drug metronidazole (IC50= 1.80 lM) used against Entamoeba histolytica, quinazolin-4(3H)- one Schiff base conjugates were synthesized and evaluated against HM1: IMSS strain of E.

histolytica.

Out of the thirteen compounds (S2-S14), six compounds (S2, S3, S4, S5, S6 and S11) were found to be better inhibitors than metronidazole and showed low cytotoxicity on HeLa cells, a cervical cancer cell line.

The structure of intermediate compound S1 was confirmed by crystal structure studies.