Oral health status, salivary MMP-8 and secretory leukocyte peptidase inhibitor (SLPI)‎ among uncontrolled type-i diabetes mellitus in Iraqi patients

الملخص EN

Back ground: diabetes is a metabolic disease characterized by hyperglycemia that results in deficiency or absence of insulin production.

The dental caries and gingivitis/periodontitis are widespread chronic diseases in diabetes.

The aim of the present study was determined the salivary matrix metalloproteinase (MMP-8), Secretory Leukocyte Peptidase Inhibitor (SLPI) and oral health status among uncontrolled diabetic group in comparison with healthy control group.

Materials and Methods: The total sample composed of 90 adults aged (18-35) years.

Divided into 60 uncontrolled diabetic patients (HbA1c >7%) and 30 healthy control group.

Unstimulated saliva was collected from each subject with type-I DM, BMI, duration of diabetes, HbA1c%, DMFT, gingival index (GI) and periodontal disease index were recorded during clinical visit.

Level of salivary MMP-8 and SLPI was measured by using ELISA immunoassay analysis.

Results: The DMFT was highly significant higher among type-I DM group than control group (p<0.001),GI and pocket depthwas significant difference (p=0.002, p<0.001 respectively) between two groups except the attachment loss with no significant difference (p=0.06).

The Salivary MMP-8 was elevated, whereas SLPI was lowered in individuals with type I diabetes mellitus in comparison to the healthy controls, but statistically was non-significant.

Analysis among uncontrolled diabetic patients revealed that the HbA1c% correlate positively significant with salivary MMP-8 (r=0.321, p=0.012), SLPI (r=0.276, P=0.033) andattachment loss (r=0.353, p=0.006); however the correlation between MMP-8 & SLPIwas a significant in negative direction (r=-0.395, p=0.002).

Conclusion:The DMFT, pocket depth and gingival index was higher in uncontrolled diabetes group.

HbA1c% was positively correlation withMMP-8, SLPI and attachment loss in uncontrolled diabetic group.

Salivary SLPI associated inversely with significant correlation with salivary MMP-8.