Immunohistochemical expression of HepPar 1 in colorectal cancer
المؤلفون المشاركون
Jasim, Islam A.
Hamidi, Amir Dh.
المصدر
Journal of the Faculty of Medicine Baghdad
العدد
المجلد 59، العدد 3 (30 سبتمبر/أيلول 2017)، ص ص. 254-257، 4ص.
الناشر
تاريخ النشر
2017-09-30
دولة النشر
العراق
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Background: Colorectal carcinoma is common in Northwest Europe, North America, and other Anglo-Saxon areas, while it decreases in number in Africa, Asia, and some parts of South America, There are many immunohistochemical markers react to colonic tissue, the large majority of colorectal carcinomas are positive for mucin stains.
Colorectal adenocarcinomas are invariably positive for cytokeratin (CK), Reactivity for CEA is also the rule; as a matter of fact, failure to detect CEA in an adenocarcinoma of makes a colo-rectal site of origin seems to be unlikely, and many other markers that could claimed in colorectal tumors, a one marker that may has a role in staining colorectal tumors is HepPar-1 which is a monoclonal antibody that reacts to an as yet unidentified cytoplasmic marker of normal and neoplastic hepatocytes, which could be expressed in neoplastic or non-neoplastic colorectal tissue.
Objectives: to see the expression of HepPar-1 (cytoplasmic marker of normal and neoplastic hepatocytes) in colorectal cancer.
Patients and methods: Fifty-eight cases (49 with colorectal carcinoma, 9 cases on non-malignant colorectal tissues) male and females depending on records, the study is conducted in GIT specialized hospital in medical city / department of histopathology – Baghdad city during period from 1/10/2016 to 1/4/2017.
Results: cases were studied, the positivity in our study of the cases was (8.2%), and none of the control "non-neoplastic" cases express this marker.
No significant statistical correlation was found between HepPar-1 expression and the tumor grade, site, age or sex, (P values >0.05).
Conclusion: HepPar-1 can be expressed in tumors including 8.2% of colorectal carcinoma in this study; HepPar-1 is not expressed in normal colorectal tissue.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jasim, Islam A.& Hamidi, Amir Dh.. 2017. Immunohistochemical expression of HepPar 1 in colorectal cancer. Journal of the Faculty of Medicine Baghdad،Vol. 59, no. 3, pp.254-257.
https://search.emarefa.net/detail/BIM-794062
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jasim, Islam A.& Hamidi, Amir Dh.. Immunohistochemical expression of HepPar 1 in colorectal cancer. Journal of the Faculty of Medicine Baghdad Vol. 59, no. 3 (Sep. 2017), pp.254-257.
https://search.emarefa.net/detail/BIM-794062
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jasim, Islam A.& Hamidi, Amir Dh.. Immunohistochemical expression of HepPar 1 in colorectal cancer. Journal of the Faculty of Medicine Baghdad. 2017. Vol. 59, no. 3, pp.254-257.
https://search.emarefa.net/detail/BIM-794062
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 256-257
رقم السجل
BIM-794062
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر