Determination of methamphetamine drug by GC-MS based on molecularly imprinted solid-phase used meth acrylic acid and acryl amide as functional monomers

الملخص EN

We developed a novel method characterized by high sensitivity, low cost and high stability .This method based on a molecularly imprinted polymer (MIP) using a functional monomer which is meth acrylic acid (MTAA), acryl amide (AAM), suitable cross-linker and the template which is MAMP to fabricate a monolithic solid-phase micro extraction (SPME) fiber .

(SPME) with gas chromatography and mass spectrometry (GC/MS); all these analytical methods used to extraction , pre-concentration and selective determination of methamphetamine (MAMP) and its derivatives.

Firmness, stability and duration of the fabricated fiber give its fundamental and indispensable role in SPME.

The aim of this study is to investigate the factors influencing the polymerization and extraction procedures also to detail the selectivity of the fabricated fiber to the template in solution containing MAMP, also the selectivity to related and unrelated compound under the optimum conditions.

The relative standard deviations )RSD%) for five patients repeated experiments for three measurements are range of (at 30 to 60 ppm of MAMP) is (1.20-3.61) %.

The relative recoveries obtained for MAMP in spiked human urine samples are in the range of (93.70-99.63) %.