Simvastatin use in patients with type 2 diabetes mellitus : the effects on oxidative stress
المؤلفون المشاركون
Rudha, Ammar R. M.
Jamil, Dina A.
al-Ubaydi, Haydar A.
Hadi, Najah R.
Abd al-Husayn, Muhammad A.
المصدر
العدد
المجلد 30، العدد 4 (31 أغسطس/آب 2015)، ص ص. 237-240، 4ص.
الناشر
المجلس العماني للاختصاصات الطبية
تاريخ النشر
2015-08-31
دولة النشر
سلطنة عمان
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Objectives: Studies have shown that people with type 2 diabetes mellitus (T2DM) may develop atherosclerosis due to the disturbance in oxidative control and progressive dyslipidemia.
Our study aimed to highlight the benefits of simvastatin treatment in improving serum lipids and reducing oxidative damage in patients with T2DM.
Methods: Our randomized control trial included 56 patients with T2DM and dyslipidemia.
The participants were on glibenclamide (5mg/day) during the period of the study.
The patients were divided into two study groups (groups 1 and 2).
Group 1 was the control group and consisted of 31 patients.
Group 2 consisted of 25 participants, who were given simvastatin 20mg tablet once daily for 12 weeks.
The control group did not receive simvastatin.
Both groups were followed-up for measurement of blood pressure, pulse rate, serum lipids, and parameters of oxidative stress.
Results: The simvastatin treated group showed a significant improvement with reduced erythrocyte glutathione compared to the control group (p<0.001).
This was also associated with a significant reduction in erythrocyte malondialdehyde in the simvastatin treated group compared to the control group (p<0.001).
Serum lipids reflected a similar improvement in the levels of erythrocyte malondialdehyde.
Conclusions: Our study highlights the beneficial role of simvastatin in improving the degree of oxidative stress in patients with T2DM through its effects on serum lipids and lipid peroxidation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hadi, Najah R.& Abd al-Husayn, Muhammad A.& Rudha, Ammar R. M.& Jamil, Dina A.& al-Ubaydi, Haydar A.. 2015. Simvastatin use in patients with type 2 diabetes mellitus : the effects on oxidative stress. Oman Medical Journal،Vol. 30, no. 4, pp.237-240.
https://search.emarefa.net/detail/BIM-798369
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hadi, Najah R.…[et al.]. Simvastatin use in patients with type 2 diabetes mellitus : the effects on oxidative stress. Oman Medical Journal Vol. 30, no. 4 (2015), pp.237-240.
https://search.emarefa.net/detail/BIM-798369
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hadi, Najah R.& Abd al-Husayn, Muhammad A.& Rudha, Ammar R. M.& Jamil, Dina A.& al-Ubaydi, Haydar A.. Simvastatin use in patients with type 2 diabetes mellitus : the effects on oxidative stress. Oman Medical Journal. 2015. Vol. 30, no. 4, pp.237-240.
https://search.emarefa.net/detail/BIM-798369
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 240
رقم السجل
BIM-798369
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر