Effect of two different doses of dexmedetomidine as adjuvant in bupivacaine induced subarachnoid block for elective abdominal hysterectomy operations : a prospective, double-blind, randomized controlled study
المؤلفون المشاركون
Chattopadhyay, Surajit
Das, Anjan
Halder, Susanta
Mandal, Parthajit
Chhaule, Subinay
Banu, Rezina
المصدر
العدد
المجلد 30، العدد 4 (31 أغسطس/آب 2015)، ص ص. 257-263، 7ص.
الناشر
المجلس العماني للاختصاصات الطبية
تاريخ النشر
2015-08-31
دولة النشر
سلطنة عمان
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objectives: Improvements in perioperative pain management for lower abdominal operations has been shown to reduce morbidity, induce early ambulation, and improve patients’ long-term outcomes.
Dexmedetomidine, a selective alpha-2 agonist, has recently been used intrathecally as adjuvant to spinal anesthesia to prolong its efficacy.
We compared two different doses of dexmedetomidine added to hyperbaric bupivacaine for spinal anesthesia.
The primary endpoints were the onset and duration of sensory and motor block, and duration of analgesia.
Methods: A total of 100 patients, aged 35–60 years old, assigned to have elective abdominal hysterectomy under spinal anesthesia were divided into two equally sized groups (D5 and D10) in a randomized, double-blind fashion.
The D5 group was intrathecally administered 3ml 0.5% hyperbaric bupivacaine with 5μg dexmedetomidine in 0.5ml of normal saline and the D10 group 3ml 0.5% bupivacaine with 10μg dexmedetomidine in 0.5ml of normal saline.
For each patient, sensory and motor block onset times, block durations, time to first analgesic use, total analgesic need, postoperative visual analogue scale (VAS) scores, hemodynamics, and side effects were recorded.
Results: Although both groups had a similar demographic profile, sensory and motor block in the D10 group (p<0.050) was earlier than the D5 group.
Sensory and motor block duration and time to first analgesic use were significantly longer and the need for rescue analgesics was lower in the D10 group than the D5 group.
The 24-hour VAS score was significantly lower in the D10 group (p<0.050).
Intergroup hemodynamics were comparable (p>0.050) without any appreciable side effects.
Conclusions: Spinal dexmedetomidine increases the sensory and motor block duration and time to first analgesic use, and decreases analgesic consumption in a dose-dependent manner
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Das, Anjan& Halder, Susanta& Chattopadhyay, Surajit& Mandal, Parthajit& Chhaule, Subinay& Banu, Rezina. 2015. Effect of two different doses of dexmedetomidine as adjuvant in bupivacaine induced subarachnoid block for elective abdominal hysterectomy operations : a prospective, double-blind, randomized controlled study. Oman Medical Journal،Vol. 30, no. 4, pp.257-263.
https://search.emarefa.net/detail/BIM-798372
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Das, Anjan…[et al.]. Effect of two different doses of dexmedetomidine as adjuvant in bupivacaine induced subarachnoid block for elective abdominal hysterectomy operations : a prospective, double-blind, randomized controlled study. Oman Medical Journal Vol. 30, no. 4 (2015), pp.257-263.
https://search.emarefa.net/detail/BIM-798372
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Das, Anjan& Halder, Susanta& Chattopadhyay, Surajit& Mandal, Parthajit& Chhaule, Subinay& Banu, Rezina. Effect of two different doses of dexmedetomidine as adjuvant in bupivacaine induced subarachnoid block for elective abdominal hysterectomy operations : a prospective, double-blind, randomized controlled study. Oman Medical Journal. 2015. Vol. 30, no. 4, pp.257-263.
https://search.emarefa.net/detail/BIM-798372
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 263
رقم السجل
BIM-798372
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر