Deciphering the role of the barr body in malignancy : an insight into head and neck cancer

الملخص EN

chromosome inactivation is the epitome of epigenetic regulation and long non-coding ribonucleic acid function.

The differentiation status of cells has been ascribed to X chromosome activity, with two active X chromosomes generally only observed in undifferentiated or poorly differentiated cells.

Recently, several studies have indicated that the reactivation of an inactive X chromosome or X chromosome multiplication correlates with the development of malignancy; however, this concept is still controversial.

This review sought to shed light on the role of the X chromosome in cancer development.

In particular, there is a need for further exploration of the expression patterns of X-linked genes in cancer cells, especially those in head and neck squamous cell carcinoma (HNSCC), in order to identify different prognostic subpopulations with distinct clinical implications.

This article proposes a functional relationship between the loss of the Barr body and the disproportional expression of X-linked genes in HNSCC development.