Ductal and acinar adenocarcinoma of prostate : morphological and immunohistochemical characterization

الملخص EN

Objectives: We sought to characterize the ductal and acinar subtype of prostate adenocarcinoma using hematoxylin and eosin (H&E) staining and an immunohistochemical antibody cocktail.

We also investigated the clinical features, prostate-specific antigen (PSA) levels, and biological aggressiveness of these tumors.

Methods: We utilized tumor bearing prostate biopsies, obtained between 2010 and 2014 from Dow Diagnostic Research and Reference Laboratory, to identify cases of prostatic ductal and acinar adenocarcinoma using routine H&E and immunohistochemical staining.

The immunohistochemical antibody cocktail 34βE12/p63/AMACR was used for staining.

The association of clinicopathological variables including patient’s age at diagnosis, Gleason score, and PSA levels before surgery was retrospectively analyzed.

Results: A total of 10 ductal and 140 non-ductal cases were identified.

Ductal cases were predominantly high grade with advanced histopathological features (90%; p=0.030).

Marked elevation in PSA level was also reported in most cases.

No other significant statistical difference was observed.

Conclusions: Pathological and immunohistochemical examination could be used to characterize ductal and acinar adenocarcinoma of the prostate.

Ductal adenocarcinoma of the prostate is a rare subtype of prostate carcinoma and is be more likely to present with advanced grade cancer suggesting that timely detection of the disease is vital.