Diagnostic biomarkers for neonatal sepsis : meta-analysis study
العناوين الأخرى
تحليل ميتا لدلائل تشخيص التسمم الدموي في الأطفال حديثي الولادة
المؤلفون المشاركون
al-Jamal, Hanan Abd Allah
Mustafa, Salih
Bakr, Salwa Ibrahim
Abu al-Ula, Huayda
المصدر
العدد
المجلد 19، العدد 71 (30 إبريل/نيسان 2016)، ص ص. 1-8، 8ص.
الناشر
جامعة عين شمس كلية الدراسات العليا للطفولة
تاريخ النشر
2016-04-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background: Neonatal sepsis is the single most important cause of neonatal deaths in the community.
It remains a major cause of mortality in newborn and life- threatening disorder in infants.
Aim: To assess the validity of using diagnostic markers in predicting neonatal sepsis.
Methodology: This was a systematic review and meta- analysis.
More than 200 potentially relevant studies were collected in 2 years standing from 2012 to 2014 but only 42 of them met the inclusion criteria.
A standard method for meta- analysis of diagnostic markers evaluation was performed using Biostat, Comprehensive Meta- analysis version 3.0 Results: Meta- analysis was performed on 2722 neonates divided into 2 groups according to their clinical manifestations of neonatal sepsis and laboratory findings.
PROM was the commonest risk factor predisposing to sepsis.
Klebsiella and staphylococcus aureus were the most common isolated organism.
Based on the results from included studies in this review, 6 predominant markers were used to evaluate early diagnosis of neonatal sepsis, PCT, 1L- 6, TNF- a, CD64, sICAM and Eselectin.
Procalcitonin was highly significantly elevated with sensitivity (0.93) whereas specificity was (0.87) and it had the most diagnostic accuracy (0.95).
SICAM was the most sensitive marker (0.95) its diagnostic accuracy and specificity were (0.93) and (0.90), TNF- a had diagnostic accuracy (0.92) sensitivity and specificity were (0.86), the sensitivity of Eselectin was (0.92), its diagnostic accuracy and specificity were (0.91) and (0.82).
IL6 had diagnostic accuracy (0.93); the specificity and sensitivity were (0.90) and (0.88).
CD64 was the most specific biomarker for predicting neonatal sepsis (0.91), sensitivity (0.87) accuracy (0.92).
Conclusion: Based on results from the studies included in this review, it was clear that serum sICAM had a high sensitivity for diagnosis of neonatal sepsis; CD64 had a high specificity and serum procalcitonin had the most diagnostic accuracy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mustafa, Salih& al-Jamal, Hanan Abd Allah& Bakr, Salwa Ibrahim& Abu al-Ula, Huayda. 2016. Diagnostic biomarkers for neonatal sepsis : meta-analysis study. Journal of Childhood Studies،Vol. 19, no. 71, pp.1-8.
https://search.emarefa.net/detail/BIM-809043
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mustafa, Salih…[et al.]. Diagnostic biomarkers for neonatal sepsis : meta-analysis study. Journal of Childhood Studies Vol. 19, no. 71 (Apr. 2016), pp.1-8.
https://search.emarefa.net/detail/BIM-809043
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mustafa, Salih& al-Jamal, Hanan Abd Allah& Bakr, Salwa Ibrahim& Abu al-Ula, Huayda. Diagnostic biomarkers for neonatal sepsis : meta-analysis study. Journal of Childhood Studies. 2016. Vol. 19, no. 71, pp.1-8.
https://search.emarefa.net/detail/BIM-809043
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 7-8
رقم السجل
BIM-809043
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر