Expression of estrogen, progesterone and human epidermal growth factor receptors in breast cancer in al-Nassiriya 2014-2015

الملخص EN

Abstract: Breast cancer is the most common malignancy and is real general well-being issue for ladies all through the world and in Iraq.

Breast cancer is an extremely heterogeneous disease, There are three predictive markers: estrogen receptors, progesterone receptors and Her2-neu receptors have independent prognostic value in breast cancer.

ER expression appears in 80-90 % of patients with breast cancer, while PR expression appear in 70-80 % of cases.Her2-neu over expression present in 15-20 % of cases(1).

Our study is a cross-sectional study carried out in Thi-qar governorate in Nasiriya city in Al Habbobi hospital –Oncology center, 165 cases of patients who were diagnosed during the period of two years (February 2014 - January 2015 ) with invasive breast cancer were included in this study .

The information of each patient were collected and analyzed which include : age of patient, sex, place of residence and tumor related information include grading, staging of tumor, status of receptors(ER, PR, HER2neu receptors).

From this study we found The mean age 49±11.1.

Most cases were PR+(75.2%) while ER+(72.7%) but most of them were HER2 negative(78.2%).

Most patients were in grade II (64.2%) and stage II (50.3%) ,The most common hormonal receptor expression was (ER/PR+ ,HER2-) which accounted for 64.8%.

Regarding to association of hormonal receptor expression with grading and staging of tumor appears that higher grade tumor (II) was observed (76.93%) in type IV (ER/PR-, Her2+) and higher stage (III) was observed (80.95%) in triple negative subtype.

Aim of Study: It is to evaluate the hormonal receptor status and their association with grading and staging of breast cancer at the time of diagnosis in Al-Nassiriya city.