Expression of the leukocyte-associated Ig-like receptor-1 on B lymphocytes from systemic lupus erythematosus patients
المؤلفون المشاركون
Usayli, Hibah A.
Radwan, Wafa M.
al-Barbari, Hani S.
Taha, Azzah A.
المصدر
Egyptian Rheumatology and Rehabilitation
العدد
المجلد 43، العدد 3 (30 سبتمبر/أيلول 2016)، ص ص. 124-130، 7ص.
الناشر
الجمعية المصرية للروماتيزم و التأهيل
تاريخ النشر
2016-09-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background The leukocyte-associated immunoglobulin (Ig)-like receptor-1 (LAIR-1) is a transmembrane molecule belonging to the Ig superfamily.
In B cells, LAIR-1 cross-linking leads to downregulation of Ig and cytokine production.
Aim of the work The aim of the present study was to assess the expression of LAIR-1 on peripheral blood B lymphocyte from systemic lupus erythematosus (SLE) patients, and its correlation with disease manifestations.
Patients and methods Twenty-two SLE female patients and 16 matched healthy controls were included in the study.
Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score was assessed.
The expression of LAIR-1 was determined by using flow cytometry.
Results The 22 SLE patients had a mean age of 25.59±4.22 years and disease duration of 5–24 months.
The mean SLEDAI was 8±1.5.
The percentage of CD19+ B lymphocytes lacking LAIR-1 was markedly increased in SLE patients (27.8 ±10.9%) compared with healthy controls (16.2±4.4%) (P<0.001).
The mean fluorescent intensity ratio (MFIR) of LAIR-1 expression on CD19+ B cells was strongly decreased in SLE patients (44.1±12.6) compared with healthy controls (58.9±7.7) (P<0.001).
The percentage of CD19+ LAIR-1− B cells significantly correlated with the complement (C4) (r=0.45, P=0.03) and the serum creatinine level (r=0.47, P=0.02), and negatively with the serum albumin level (r=−0.57, P=0.005).
The MFIR of LAIR-1 significantly correlated with the serum albumin level (r=0.74, P<0.001) and negatively correlated with the serum creatinine level (r=−0.43, P=0.041).
There was no significant association of LAIR− (%) or the MFIR with the clinical manifestations of the patients.
Conclusion Thisstudypointsout that thelackofLAIR-1expressiononBcells fromSLEpatientscould beatrigger for thedysregulationofantibody productioninSLE,andisassociatedwiththe degreeof renalaffectionasevidencedby thesignificant correlationwith serumcreatinine levels and negative correlation with the levels of serum albumin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Usayli, Hibah A.& Radwan, Wafa M.& al-Barbari, Hani S.& Taha, Azzah A.. 2016. Expression of the leukocyte-associated Ig-like receptor-1 on B lymphocytes from systemic lupus erythematosus patients. Egyptian Rheumatology and Rehabilitation،Vol. 43, no. 3, pp.124-130.
https://search.emarefa.net/detail/BIM-813373
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Usayli, Hibah A.…[et al.]. Expression of the leukocyte-associated Ig-like receptor-1 on B lymphocytes from systemic lupus erythematosus patients. Egyptian Rheumatology and Rehabilitation Vol. 43, no. 3 (Jul. / Sep. 2016), pp.124-130.
https://search.emarefa.net/detail/BIM-813373
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Usayli, Hibah A.& Radwan, Wafa M.& al-Barbari, Hani S.& Taha, Azzah A.. Expression of the leukocyte-associated Ig-like receptor-1 on B lymphocytes from systemic lupus erythematosus patients. Egyptian Rheumatology and Rehabilitation. 2016. Vol. 43, no. 3, pp.124-130.
https://search.emarefa.net/detail/BIM-813373
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 129-130
رقم السجل
BIM-813373
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر