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Antagonistic effect between Citrullus colocynthis extract and TiO2 nanoparticles in anticancer combination therapy
العناوين الأخرى
التأثير التضادري بين مستخلص نبات الحنظل و دقائق ثاني أوكسيد التيتانيوم النانوية في العلاج التجميعي للسرطان
المؤلف
المصدر
Iraqi Journal of Cancer and Medical Genetics
العدد
المجلد 9، العدد 2 (31 ديسمبر/كانون الأول 2016)، ص ص. 195-204، 10ص.
الناشر
الجامعة المستنصرية المركز العراقي لبحوث السرطان و الوراثة الطبية
تاريخ النشر
2016-12-31
دولة النشر
العراق
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The objective of this study is to determine the level of some element and chemical components of aquatic extract of fruit of Citrullus colocynthis and study the cytotoxic effect of crude extract of plant alone and TiO2 nanoparticles (NPs) alone on two cancer cell lines: Glioblastoma-Multiforme cell culture (AMGM), mice mammary carcinoma cell line 2003 (AMN3) and Recombinant mouse epithelial cell line expressing human poliovirus receptor (CD155) on the cell surface (L20B) compared with combination of them in vitro.
The levels of Cu, Cd, Mn, K, Fe, Co, Zn, N and Ti were very low and phosphor was absent.
The level of total proteins was 0.138 %.
Twenty nine compounds were identi ed by GC-MS.
The major components were 2,3-Dihydroxypropyl elaidate (30.33 %), followed by 9,12-Octadecadienoic acid (Z,Z)- (29.36 %).
All concentrations of plant extract reduced cellular viability of both cancer cell lines, (AMN3 and AMGM), compared with control.
The IC50 value was 8.6 mg/ml and 0.013 mg/ml respectively.
While there were no effect on L20B cell line.
In the treat- ment of TiO2 NPs, there were reductions in AMN3 cell proliferation in the concentrations (0.2 mg/ml- 0.02 μg/ml).
IC50 value was (0.42 mg/ml).
While the reduction in AMGM cell line was observed at 2 mg/ml- 0.2 μg/ml concentrations.
IC50 value was 0.05 mg/ml.
In combination treatment against AMN3 cell line, most concentrations of combination’s treatment, except the high concentra- tions, reduced cell viability.
IC50 value was 1.25 mg/ml of plant with 0.47 mg/ml of NPs.
The same were found with AMGM cell line.
IC50 value was 6.35 mg/ml of plant combined by 0.635 mg/ml of NPs.
All combination points located in the antagonism area in AMN3 and AMGM.
Although there were good anticancer activities of each of plant extract and nanoparticles alone but there were Antagonistic effect between them in combination therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Jalil, Raghad Diya. 2016. Antagonistic effect between Citrullus colocynthis extract and TiO2 nanoparticles in anticancer combination therapy. Iraqi Journal of Cancer and Medical Genetics،Vol. 9, no. 2, pp.195-204.
https://search.emarefa.net/detail/BIM-818975
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Jalil, Raghad Diya. Antagonistic effect between Citrullus colocynthis extract and TiO2 nanoparticles in anticancer combination therapy. Iraqi Journal of Cancer and Medical Genetics Vol. 9, no. 2 (2016), pp.195-204.
https://search.emarefa.net/detail/BIM-818975
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Jalil, Raghad Diya. Antagonistic effect between Citrullus colocynthis extract and TiO2 nanoparticles in anticancer combination therapy. Iraqi Journal of Cancer and Medical Genetics. 2016. Vol. 9, no. 2, pp.195-204.
https://search.emarefa.net/detail/BIM-818975
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
رقم السجل
BIM-818975
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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