دور مادة Quercetin في تلطيف الآثار الجانبية للعقار الكيماوي Doxorubicin في مستوى Troponin و بعض الإنزيمات القلبية في ذكور الأرانب المحلية

الملخص EN

The study aim to detect the treatment effect of Quercetin in mitigation the toxic effect of Doxorubicin drug in heart function in 32 local male rabbits divided randomly into four equal groups treated for 28 days as follow; Control group given daily distilled water orally and injected with 4ml normal saline weekly.

First treatment group given orally 10mg/kg Quercetin daily and injected with 4ml normal saline weekly.

Second treatment group injected with 4mg/kg doxorubicin weekly and given daily distilled water orally.

The third treatment group given 10mg/kg Quercetin daily and injected with 4mg/kg doxorubicin weekly.

Results showed a significant (P<0.05) increase of Troponin, CK-MB and LDH levels in second group treated with doxorubicin only compared with normal levels of these parameters in control group, conversely there is positive interrelating non significant (P>0.05) among control group and other groups which treated with Quercetin, first as well as third groups in which Quercetin reduces all parameters significantly (P<0.05).

In conclusion; The Quercetin has important role in reduced negative side effects of Doxorubicin in heart function.