The effect of probiotic and or prebiotic on liver function tests in patients with nonalcoholic fatty liver disease : a double blind randomized clinical trial
المؤلفون المشاركون
Javadi, Layla
Ghavami, Mustafa
Khoshbaten, Manouchehr
Barzegari, Abu al-Fadl
Gargari, Bahram Pourghassem
Safaiyan, Abd al-Rasul
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 19، العدد 4 (30 إبريل/نيسان 2017)، ص ص. 1-9، 9ص.
الناشر
تاريخ النشر
2017-04-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background: Oral administration of pro- and prebiotics has recently been considered as an effective way for nonalcoholic fatty liver disease (NAFLD) recovery.
Objectives: The current study aimed at evaluating the effect of supplementation with probiotics and/or prebiotics on liver function tests in patients with NAFLD.
Methods: In this double blind, placebo-control clinical trial, 75 subjects with NAFLD were voluntarily recruited from May 2013 to March 2014, in Iran.
Participants were randomly assigned to 1 of 4 groups using a block randomization procedure.
Group 1 received probiotic capsules (Bifidobacterium longum (BL) and Lactobacillus acidophilus (LA): 2 107 CFU/day), group 2 received prebiotic inulin high performance (HP): 10 g/day, group 3 received probiotic and the prebiotic, and group 4 received a placebo for 3 months.
The sample size was determined on the basis of a primary outcome of a change in aspartate aminotransferase (AST) level.
Results: Anintergroup comparison indicated that the AST (P = 0.006) and alanine aminotransferase (ALT) (P = 0.04) levels decreased at the end of the study.
Aspartate Aminotransferase (mean difference of group1 versus placebo with P value of 0.001, group2 versus placebo with P value of 0.045, group3 versus placebo with P value of 0.015) and ALT (mean difference of group 1 versus placebo with P value of 0.009, group 2 versus placebo with P value of 0.041, and group 3 versus placebo with P value of 0.046) serum levels decreased significantly in all of the intervention groups compared to the placebo.
The grade of fatty liver in group 1 (P of 0.027, and number needed to treat (NNT) = 3) and group 3 (P = 0.019 and NNT = 3) decreased compared to the placebo group with no significant changes in group 2.
Conclusions: Supplementation with probiotics and/or prebiotics improvedaminotransferase enzymes, andsupplementation with probiotics or pro- and prebiotics recovered the grade of fatty liver in NAFLD patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Javadi, Layla& Ghavami, Mustafa& Khoshbaten, Manouchehr& Safaiyan, Abd al-Rasul& Barzegari, Abu al-Fadl& Gargari, Bahram Pourghassem. 2017. The effect of probiotic and or prebiotic on liver function tests in patients with nonalcoholic fatty liver disease : a double blind randomized clinical trial. Iranian Red Crescent Medical Journal،Vol. 19, no. 4, pp.1-9.
https://search.emarefa.net/detail/BIM-820696
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Javadi, Layla…[et al.]. The effect of probiotic and or prebiotic on liver function tests in patients with nonalcoholic fatty liver disease : a double blind randomized clinical trial. Iranian Red Crescent Medical Journal Vol. 19, no. 4 (Apr. 2017), pp.1-9.
https://search.emarefa.net/detail/BIM-820696
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Javadi, Layla& Ghavami, Mustafa& Khoshbaten, Manouchehr& Safaiyan, Abd al-Rasul& Barzegari, Abu al-Fadl& Gargari, Bahram Pourghassem. The effect of probiotic and or prebiotic on liver function tests in patients with nonalcoholic fatty liver disease : a double blind randomized clinical trial. Iranian Red Crescent Medical Journal. 2017. Vol. 19, no. 4, pp.1-9.
https://search.emarefa.net/detail/BIM-820696
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 8-9
رقم السجل
BIM-820696
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر