التصميم الدوائي بمساعدة الحاسوب لمثبطات جديدة مشتقة من نواة الأدنين لبروتينات الصدمة الحرارية 91 كاستراتيجية جديدة في معالجة السرطان

الملخص EN

Heat shock protein 90 (Hsp90) is an ATP dependent protein essential for regulating cellular homeostasis and promoting cell survival.

Hsp90 plays an important role in conformational regulation of cellular proteins implicated in oncogenesis.

Hsp90 has emerged as a new target for cancer chemotherapy.

This article will briefly discuss our work in designing novel adenine derived inhibitors of heat shock protein 90 by computer modeling method.