Starvation based differential chemotherapy : a novel approach for cancer treatment
المؤلفون المشاركون
Abd al-Salam, Aftab Ahmad
Naveed, Sidra
Aslam, Muhammad
المصدر
العدد
المجلد 29، العدد 6 (31 ديسمبر/كانون الأول 2014)، ص ص. 391-398، 8ص.
الناشر
المجلس العماني للاختصاصات الطبية
تاريخ النشر
2014-12-31
دولة النشر
سلطنة عمان
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Cancer patients undergoing chemotherapy treatment are advised to increase food intake to overcome the therapy-induced side effects, and weight loss.
Dietary restriction is known to slow down the aging process and hence reduce age-related diseases such as cancer.
Fasting or short-term starvation is more effective than dietary restriction to prevent cancer growth since starved cells switch off signals for growth and reproduction and enter a protective mode, while cancer cells, being mutated, are not sensitized by any external growth signals and are not protected against any stress.
This phenomenon is known as differential stress resistance (DSR).
Nutrient signaling pathways involving growth hormone/insulin-like growth factor-1 axis and its downstream effectors, play a key role in DSR in response to starvation controlling the other cell maintenance systems, such as autophagy and apoptosis, that are related to the tumorigenesis.
Yeast cells lacking these effectors are better protected against oxidative stress compared to normal cells.
In the same way, starvation protects many cell lines and mice against high-dose chemotherapeutic drugs.
According to a series of studies, fasting results in overall reduction in chemotherapy side effects in cancer patients.
Data shows that starvation-dependent differential chemotherapy is safe, feasible and effective in cancer treatment, but the possible side effects of starvation limit its efficacy.
However, further studies and clinical trials may result in its implementation in cancer treatment
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Naveed, Sidra& Aslam, Muhammad& Abd al-Salam, Aftab Ahmad. 2014. Starvation based differential chemotherapy : a novel approach for cancer treatment. Oman Medical Journal،Vol. 29, no. 6, pp.391-398.
https://search.emarefa.net/detail/BIM-831856
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Naveed, Sidra…[et al.]. Starvation based differential chemotherapy : a novel approach for cancer treatment. Oman Medical Journal Vol. 29, no. 6 (2014), pp.391-398.
https://search.emarefa.net/detail/BIM-831856
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Naveed, Sidra& Aslam, Muhammad& Abd al-Salam, Aftab Ahmad. Starvation based differential chemotherapy : a novel approach for cancer treatment. Oman Medical Journal. 2014. Vol. 29, no. 6, pp.391-398.
https://search.emarefa.net/detail/BIM-831856
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 396-398
رقم السجل
BIM-831856
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر