Epidemiology of fungaemia and associated risk factors among patients in a tertiary care hospital in Saudi Arabia

العناوين الأخرى

وبائية الفطريات في الدم و عوامل الخطورة المصاحبة للمرضى في مستشفى تخصصي في المملكة العربية السعودية

المؤلف

Sadi, Abd al-Rahman Tawfiq

المصدر

Duhok Medical Journal

الناشر

جامعة دهوك كلية الطب

تاريخ النشر

2012-12-31

دولة النشر

العراق

عدد الصفحات

7

التخصصات الرئيسية

الطب البشري

الملخص الإنجليزي

Background and objectives This study was conducted in-order to assess the epidemiology of fungaemia among hospitalized patients and to identify the risk factors associated with fungaemia in critical care units.

Methods: Blood cultures (24087 bottles) from all medical units at high infective risk mainly from intensive care unit and Nursery wards in Ohud Hospital in Madina Al-Munawara in Saudi Arabia were sent to Microbiology laboratory.

A minimum of 5 mL of blood was collected aseptically by skin venepuncture and inoculated into a BacTec aerobic vial (Becton Dickinson) and incubated for 7 days.

All positive cultures were inoculated on Sabouraud glucose agar (SGA) and incubated at 30 0C.

An aliquot was Gram-stained for preliminary identification of the microorganism.

C.

albicans were identified based on colonial morphology and germ tube formation.

Results: A total of 115 cases of blood culture positive for fungi were identified out of 2875 positive bottles during 7 year period (2005-2011).

The majority of episodes were due to Candida albicans: 60 (52%) followed by candida non-albicans: 53 (46%), and only 2 cases (2%) of non- candida spp (Aspergillus spp).

The overall mortality was 32%.

In Nursery ward there were 59 (51%) cases of yeast in blood culture, among these episodes, 48 (81%) were positive for Candida albicans, and 11 (19%) were Candida non-albicans.

The two main risk factors were: first prematurity and Respiratory Distress Syndrome (RDS): 48%.

Second the use of 2 antibiotics combined or more: 71%.

In adult Intensive care unit and other medical wards there were 56 (49%) positive cases.

12 (21%) episodes were Candida albicans, 42 (75%) were Candida non-albicans and only 2 (4%) were non-candida spp (Aspergellus spp).

The associated risk factors in ICU were: diabetes: 18 cases (39%), respiratory disorders: 9 cases (20%), CVA: 6 cases (13%), post –operative; CNS infection and liver disorders: 3 cases (6.5%) each.

There were also 2 cases (4.5%) for each of anaemia and septic shock.

Conclusions: this study highlighted the importance of candidemia among hospitalized patients.

There was high percentage 81% of Candida albicans among fungaemic cases in Nursery Unit but Candida non-albicans constituted 75% among fungaemic cases in adult ICU.

نوع البيانات

أوراق مؤتمرات

رقم السجل

BIM-831962

• APA
• MLA
• AMA