The effect of loxoprofen sodium on salivary concentration of substance p following surgical removal of impacted mandibular third molar

العناوين الأخرى

تأثير عقار لوكسوبروفين الصوديوم على التركيز اللعابي للمادة بي بعد القلع الجراحي لسن العقل المطمور في الفك السفلي

المؤلفون المشاركون

Muhammad, Rafat A.
Minwah, Bara S.
al-Sanduk, Tahani A.

المصدر

Duhok Medical Journal

الناشر

جامعة دهوك كلية الطب

تاريخ النشر

2012-12-31

دولة النشر

العراق

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري

الملخص الإنجليزي

Aim: To evaluate the efficacy of loxoprofen sodium on substance P salivary concentration after the surgical removal of mandibular wisdom tooth.

Methods: Surgical removal of mandibular third molar was performed in two groups of individuals, total of fifty patients were anticipated in this study.

All were medically fit, their average of age 24.48± 5.27 (ranged 17-38); each group consisted of twenty five patients.

Group A: Preoperative 120 mg loxoprofen sodium oral capsule 30 minutes prior surgical operation; group b: placebo or control group where 120 mg glucose oral capsule 30 minutes prior surgical operation was applied.

all patients received post operatively amoxicillin capsules 500 mg t.i.d, metronidazole tablet 500mg t.i.d, and supplementary paracetamol 500 mg tablet as required.

Salivary concentration of substance P was measured by ELISA.

Pain was assessed by verbal pain scale, and duration of postoperative analgesia which recorded between groups.

Results: Postoperative salivary concentrations of substance P, verbal pain scale, and duration of postoperative analgesia in drug group was significantly lower than those in control group (P<0.05).

Conclusions: Preoperative loxoprofen sodium reduced postoperative concentrations of substance P in saliva.

Substance P salivary levels significantly increased at first day following surgical removal of impacted mandibular third molar and it’s seem to be correlated with postoperative pain

نوع البيانات

أوراق مؤتمرات

رقم السجل

BIM-832014

• APA
• MLA
• AMA