levels of salivary biochemical's in periodontitis and related diseases

الملخص EN

Background and objectives: Periodontitis is one of the most wide spread disease in the world, and its prevalence in the center of Erbil city was high.

Saliva was used as a noninvasive diagnostic fluid to measure chemical parameters released during oral diseases (especially sialic acid in periodontitis).

Method: This study included total sample of (286) individuals.

They consisted of (149) males and (137) females.

They included two age groups (18-44) years and (45-75) years.

The individuals were distributed into 161 periodontitis patients, 59 patients of clinical controls, also 66 healthy individuals as controls.

The levels of the following chemical biomarkers in both supernatant and sediment of saliva were measured: total sialic acid and its fractions (include; free sialic acid, lipid bound sialic acid and protein bound sialic acid), total calcium, total proteins.

Results: The levels of salivary biochemical parameters in periodontitis were higher than that of controls and clinical controls groups, except for some biochemical parameters in some groups of clinical controls.

These groups were medicated mild inflammable group which showed non-significant difference with periodontitis in total proteins and total calcium.

Also in gingivitis group there was a similarity in total calcium with periodontitis.

In caries group protein bound sialic acid especially in sediment of saliva also showed a nonsignificant difference with periodontitis.

Conclusion: This study revealed that salivary total lipid bound sialic acid (TLSA) had significant role in raising total sialic acid in periodontitis and can be used with (TSA) in diagnosis of periodontitis of dentate.

While the roles of total salivary; calcium (except in smoker) protein and protein bound sialic acid were no significant in periodontitis.