Effect of landfill leachates extract of Erbil city on abnormal sperm morphology and chromosomal aberrations in male albino mice

الملخص EN

This study examined the potential mutagenic effects of leachates from Erbil landfill which located at Kani- Kerzhala area south-west of the city through using mice bone marrow chromosome aberration assay and epididymis and vas Sperm abnormality assay.

Raw leachate obtained directly from the landfill and simulated leachate obtained via the American Society for Testing and Materials (ASTM) category-A extraction procedure examined for their physical and chemical properties.

Different concentrations (2.5%, 5%, 10%, and 15%) of the leachate were administered intraperitoneally for two consecutive days to male Swiss albino mice (5 mice/group).

The increase in the number of sperm obtains with abnormal morphology through using the test mixtures induced a dose-dependent, and statistical analysis shows significant differences (P < 0.01) confirm this results.

The bone marrow cells examined post treatment show structural chromosomal abnormalities such as chromosome breaks, chromosome gaps, ring chromosome, and acentrics chromosome.

The induction was dose dependent.

The result of present study indicate that landfill leachates can induce genotoxicity in mouse and suggest potential health risk to human populations.

There is the need for a shift from waste disposal to sustainable waste management.

Awareness about possible health impacts or consequences of exposure to solid waste should also be illustrated through health education.