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Role of diagnostic factors associated with antioxidative status and expression of matrix metalloproteinases (MMPs) in patients with cancer therapy induced ocular disorders
المؤلفون المشاركون
Karim, Sajjad
Mirza, Zinat
Ashraf, Muhammad Abd al-Basit
Aruj, Mahwish
Kiran, Asia
Waquar, Sulayman
Ayyaz, Ujala
Zahid, Aishah
Abd al-Jabbar
Zayn, Maryam
Raza, Amir
Mahmud, Asim
Qaisrani, Tahir Batul
Haqui, Absarul
Malik, Arif
al-Qahtani, Muhammad Husayn Muhammad
Rasul, Mahmud
Zahir, Ahmad
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 25، العدد 8 (31 ديسمبر/كانون الأول 2018)، ص ص. 1724-1728، 5ص.
الناشر
تاريخ النشر
2018-12-31
دولة النشر
السعودية
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Cancer patients when treated with different chemotherapeutic drugs often develop mild to severe sight threatening diseases during or after chemotherapy.
The mechanism involved in the pathogenesis of ocular toxicities is poorly understood.
Oxidative stress, inflammation and MMPs (angiogenic factor) are involved in the progression of chemotherapy related ocular disorders.
Materials and methods: The concentration of oxidative stress markers such as MDA, NO and levels of different antioxidant molecules such as SOD, CAT, GSH, GPx, GPr, VIT A, VIT E and VIT C present in the serum of chemotherapy treated patients (n = 50) and in normal persons (n = 20) were estimated by the direct spectrophotometric method while the concentration of TNF-a and MMP-9 activity were determined using human TNF-a and MMP-9 ELISA kits.
Results: The concentration of SOD and CAT (0.356 ± 0.05 lg/dl and 1.26 ± 0.01 lmol/mol of protein) was significantly lower as compared to that (1.09 ± 0.03 lg/dl and 3.99 ± 0.04 lmol/mol of protein) in controls.
The levels of GPx (0.06 ± 0.01 mmol/dl) in the cancer patients were much lower than those in the controls (0.78 ± 0.06 mmol/dl).
Lower level of GSH (0.96 ± 0.003 lg/dl) in serum of the diseased group was observed as compared to healthy group (7.26 ± 1.40 lg/dl).
The level of Vit A, Vit C and Vit E was lower in systemic circulation of cancer patients (109.99 ± 6.35 lg/ml, 1.26 ± 0.36 lg/ml and 1.29 ± 0.191 lg/ml) as compared to control subjects (166.35 ± 14.26 lg/ml, 3.25 ± 0.099 lg/ml and 6.354 ± 2.26 lg/ml) respectively.
The concentration of nitric oxide was significantly higher in the cancer patients (45.26 ± 6.35 ng/ml) than that in the normal subjects (16.35 ± 3.26 ng/ml).
The higher concentration of MDA (8.65 ± 3.26 nmol/ml) was observed in the patients than normal ones (1.254 ± 0.065 nmol/ml).
The quantity of TNF-a was significantly higher in chemotherapy treated patients (32.68 ± 4.33 pg/ml) as compared to the control group (20.979 ± 1.98 pg/ml).
Significantly higher concentration of MMP-9 (40.26 ± 3.26 ng/ml) was observed in the cancer patients than the controls (7.256 ± 1.95 ng/ml).
Conclusion: Lower levels of antioxidant enzymes and non-enzymatic small molecules and higher levels of oxidative stress and inflammatory clinical parameters such as NO, MDA, TNF-a and MMP-9 may be involved in the pathogenesis of systemic chemotherapy related ocular complications such as cataract, glaucoma, blepharitis, retinitis pigmentosa, macular degeneration, pterygium and retinal degeneration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rasul, Mahmud& Malik, Arif& Ashraf, Muhammad Abd al-Basit& Aruj, Mahwish& Kiran, Asia& Waquar, Sulayman…[et al.]. 2018. Role of diagnostic factors associated with antioxidative status and expression of matrix metalloproteinases (MMPs) in patients with cancer therapy induced ocular disorders. Saudi Journal of Biological Sciences،Vol. 25, no. 8, pp.1724-1728.
https://search.emarefa.net/detail/BIM-835114
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rasul, Mahmud…[et al.]. Role of diagnostic factors associated with antioxidative status and expression of matrix metalloproteinases (MMPs) in patients with cancer therapy induced ocular disorders. Saudi Journal of Biological Sciences Vol. 25, no. 8 (Dec. 2018), pp.1724-1728.
https://search.emarefa.net/detail/BIM-835114
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rasul, Mahmud& Malik, Arif& Ashraf, Muhammad Abd al-Basit& Aruj, Mahwish& Kiran, Asia& Waquar, Sulayman…[et al.]. Role of diagnostic factors associated with antioxidative status and expression of matrix metalloproteinases (MMPs) in patients with cancer therapy induced ocular disorders. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 8, pp.1724-1728.
https://search.emarefa.net/detail/BIM-835114
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1728
رقم السجل
BIM-835114
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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